| Carbon nanotubes reinforced hollow fiber solid phase microextraction for the determination of strychnine and brucine in urine | |
| Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Song XY(宋昕玥)1,2,3 ; Shi YP(师彦平)1,2; Chen J(陈娟)1,2; Chen J(陈娟)
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| 2013 | |
| Source Publication | Talanta
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| ISSN | 0039-9140 |
| Volume | 116Pages:188-194 |
| Abstract | A mixed matrix membrane (MMM), based on carbon nanotubes (CNTs) and hollow fiber (HF), was prepared and combined with solid phase microextraction (SPME) mode to determine strychnine and brucine in urine. This MMM was prepared by dispersing CNTs in water via surfactant assistance, and then immobilizing CNTs into the pores of HF by capillary forces and sonification. The prepared carbon nanotubes reinforced hollow fiber (CNTs–HF) was subsequently wetted by a few microliters of organic solvent (1-octanol), and then applied to extract the target analytes in direct immersion sampling mode. After extraction, analytes were desorbed via ultrasonic-assisted effect, and then detected via highperformance liquid chromatography (HPLC). To achieve the highest extraction efficiency, main extraction parameters such as the type and amount of surfactant, the diameter and doping level of CNTs, extraction time, desorption condition, pH value, stirring rate and volume of the donor phase were optimized. Under the optimum extraction conditions, the method showed good linearity ranges with correlation coefficients higher than 0.9990, good repeatability and batch-to-batch reproducibility with relative standard deviations (RSDs) less than 6% and 5% for strychnine and brucine, respectively, and low limits of detection (0.7 and 0.9 μg L−1 for strychnine and brucine, respectively). The recoveries were in the range of 83.81–116.14% at three spiked levels. The developed method was successfully applied to real urine sample with mean relative recoveries of 94.28% and 91.30% for strychnine and brucine, respectively. The developed method shows comparable results against reference methods and is a simple, green, and cost-effective microextraction technique. |
| Keyword | Multi-walled Carbon Nanotubes Hollow Fiber Solid-phase Microextraction Surfactant Strychnine Brucine |
| Subject Area | 分析化学与药物化学 |
| DOI | 10.1016/j.talanta.2013.05.025 |
| Funding Organization | the National Nature Science Foundation of China (Nos. 21105106;21075127);Natural Science Foundation of Gansu Province (No.1107RJZA146) |
| Indexed By | SCI |
| If | 3.511 |
| Language | 英语 |
| Funding Project | 药物化学成分研究组 |
| compositor | 第一作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/4636 |
| Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Corresponding Author | Chen J(陈娟) |
| Affiliation | 1.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China |
| Recommended Citation GB/T 7714 | Song XY,Shi YP,Chen J,et al. Carbon nanotubes reinforced hollow fiber solid phase microextraction for the determination of strychnine and brucine in urine[J]. Talanta,2013,116:188-194. |
| APA | Song XY,Shi YP,Chen J,&陈娟.(2013).Carbon nanotubes reinforced hollow fiber solid phase microextraction for the determination of strychnine and brucine in urine.Talanta,116,188-194. |
| MLA | Song XY,et al."Carbon nanotubes reinforced hollow fiber solid phase microextraction for the determination of strychnine and brucine in urine".Talanta 116(2013):188-194. |
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| File Name/Size | DocType | Version | Access | License | ||
| Talanta(2013-SunXY).（1242KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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