| Magnetic molecularly imprinted polymer for the selective extraction of sildenafil, vardenafil and their analogs from herbal medicines | |
| Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Chen FF(陈方方)1,2,3; Jie XY(解笑瑜)1,2,3; Shi YP(师彦平)1,2 ; Shi YP(师彦平)
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| 2013 | |
| Source Publication | Talanta
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| ISSN | 0039-9140 |
| Volume | 115Pages:482-489 |
| Abstract | The successfully developed magnetic molecularly imprinted polymers (MMIPs) toward six synthetic phosphodiesterase type-5 (PDE-5) inhibitors were described. Sildenafil was used as template for the preparation of MMIPs using superparamagnetic core–shell nanoparticle as supporter. The obtained MMIPs were characterized using transmission electron microscope, Fourier transform infrared, X-ray diffraction, and vibrating sample magnetometer. High performance liquid chromatography (HPLC) with diode array detector (DAD) was used for the analysis of target analytes. The application of MMIPs as selective sorbent in the cleanup of herbal medicine samples prior to HPLC offered simple sample preparation. The adsorption capacity and selectivity of prepared MMIPs and magnetic non-molecularly imprinted polymers were investigated. The binding isotherms were obtained for sildenafil and fitted by Freundlich isotherm model. Structurally similar compound of sildenafil and a reference compound protocatechuic acid were used for investing the selective recognition of MMIPs. |
| Keyword | Magnetic Molecularly Imprinted Polymers Herbal Medicines Phosphodiesterase Type-5 Inhibitors Sildenafil Solid Phase Extraction |
| Subject Area | 分析化学与药物化学 |
| DOI | 10.1016/j.talanta.2013.06.009 |
| Funding Organization | the National Natural Science Foundation of China (Nos. 21075127;20875095) |
| Indexed By | SCI |
| If | 3.511 |
| Language | 英语 |
| Funding Project | 药物化学成分研究组 |
| compositor | 第一作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/4635 |
| Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Corresponding Author | Shi YP(师彦平) |
| Affiliation | 1.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Chem Northwest Plant Resources, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China |
| Recommended Citation GB/T 7714 | Chen FF,Jie XY,Shi YP,et al. Magnetic molecularly imprinted polymer for the selective extraction of sildenafil, vardenafil and their analogs from herbal medicines[J]. Talanta,2013,115:482-489. |
| APA | Chen FF,Jie XY,Shi YP,&师彦平.(2013).Magnetic molecularly imprinted polymer for the selective extraction of sildenafil, vardenafil and their analogs from herbal medicines.Talanta,115,482-489. |
| MLA | Chen FF,et al."Magnetic molecularly imprinted polymer for the selective extraction of sildenafil, vardenafil and their analogs from herbal medicines".Talanta 115(2013):482-489. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| Talanta-2013(ChenFF)（1595KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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