Effects of Biomimetic Micropatterned Surfaces on the Adhesion and Morphology of Cervical Cancer Cells | |
Department | 固体润滑国家重点实验室(LSL) |
Zhang XH(张晓慧)1; Zhang T(张婷)2; Liu B(刘斌)2; Zhang Y(张昀)3; Ji ZY(姬忠莹)4,5; Wang XL(王晓龙)4 | |
The second department | 3d打印摩擦器件课题组 |
2022-05-27 | |
Source Publication | ACS Omega |
Volume | 7Issue:23Pages:19913–19919 |
Abstract | It has been demonstrated that micropatterned surfaces have an important influence on modulating cellular behavior. In recent years, with the rapid development of microfabrication techniques and in-depth study of nature, an increasing number of patterned structures imitating natural organisms have been successfully fabricated and widely evaluated. However, there are only a few reports about biomimetic patterned microstructures in biologically related fields. In our work, micropatterned polydimethylsiloxane (PDMS) was fabricated by mimicking the surface microstructures of natural Trifolium and Parthenocissus tricuspidata leaves using the template duplication method. The interactions between the two types of biomimetic micro-PDMS surfaces and two kinds of human cervical cancer cells (HeLa and SiHa) were investigated. HeLa and SiHa cells cultured on the two micropatterned PDMS samples exhibited more stretchable morphology, higher diffusion, and a much lower nuclear/cytoplasmic ratio than those cultured on flat PDMS surfaces, indicating a higher adhesion area of the cells. Both of the micro-PDMS substrates were found to induce significantly different morphological changes between HeLa and SiHa cells. This suggests that the micropatterned structure affects cell adhesion and morphology correlated with their surface geometric structure and roughness. The results reveal that biomimetic micropatterned surfaces from natural leaves significantly regulate the morphology and adhesion behavior of cervical cancer cells and are believed to be the new platforms for investigating the interaction between cells and substrates. |
MOST Discipline Catalogue | 理学 |
DOI | 10.1021/acsomega.2c01703 |
URL | 查看原文 |
Indexed By | SCI |
If | 4.1 |
Language | 英语 |
compositor | 第五作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/30199 |
Collection | 固体润滑国家重点实验室(LSL) |
Corresponding Author | Zhang Y(张昀); Ji ZY(姬忠莹); Wang XL(王晓龙) |
Affiliation | 1.School of Stomatology, Key Laboratory of Oral Diseases of Gansu Province, Northwest Minzu University, Lanzhou 730000, China 2.School/Hospital of Stomatology, Lanzhou University, Lanzhou 730000, China 3.Lanzhou Stomatology Hospital, Lanzhou 730000, China 4.State Key Laboratory of Solid Lubrication, , Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China 5.Shandong Laboratory of Yantai Advanced Materials and Green Manufacturing Yantai Zhongke Research Institute of Advanced Materials and Green Chemical Engineering Yantai 264006, China |
Recommended Citation GB/T 7714 | Zhang XH,Zhang T,Liu B,et al. Effects of Biomimetic Micropatterned Surfaces on the Adhesion and Morphology of Cervical Cancer Cells[J]. ACS Omega,2022,7(23):19913–19919. |
APA | Zhang XH,Zhang T,Liu B,Zhang Y,Ji ZY,&Wang XL.(2022).Effects of Biomimetic Micropatterned Surfaces on the Adhesion and Morphology of Cervical Cancer Cells.ACS Omega,7(23),19913–19919. |
MLA | Zhang XH,et al."Effects of Biomimetic Micropatterned Surfaces on the Adhesion and Morphology of Cervical Cancer Cells".ACS Omega 7.23(2022):19913–19919. |
Files in This Item: | ||||||
File Name/Size | DocType | Version | Access | License | ||
zhang-et-al-2022-eff(5981KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text |
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment