| Dammarane Triterpenoids with Rare Skeletons from Gynostemma pentaphyllum and Their Cytotoxic Activities | |
| Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Jun Wang1,2; Xian-Hua Meng2,3; Wei-Feng Wang2,3; Chun-Yan Sang3; Thi-Kim-Quy Ha4; Jun-Li Yang3
| |
| The second department | 药物化学与新药分子研究团队 |
| 2022 | |
| Source Publication | Fitoterapia
 |
| Issue | 162Pages:105280 |
| Abstract | Three unreported dammarane-type triterpenoids with rare skeletons (1–3), along with one undescribed gypenoside (4), were isolated from the aerial parts of Gynostemma pentaphyllum using diverse chromatographic materials and pre-HPLC. Their structures were elucidated on the basis of spectroscopic and spectrometric data, while the absolute configurations of 1–3 were assessed via electronic circular dichroism (ECD) analyses. Notably, compounds 1–3 possess a 3,19-hemiketal bridge in the A ring. Saponin 4 possesses an unreported 20,25-oxa structural moiety. Their antiproliferative effects against HepG2, MCF-7, and DU145 cell lines were screened. Compounds 1–3 displayed moderate cytotoxicity with IC50 values ranging from 13.7 ± 0.2 to 32.0 ± 1.7 μM. |
| Keyword | Gynostemma pentaphyllum (Thunb.) Makino Cucurbitaceae Triterpenes, cytotoxic activities |
| DOI | 10.1016/j.fitote.2022.105280 |
| If | 3.204 |
| Language | 英语 |
| compositor | 第三作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/29279 |
| Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Corresponding Author | Jun-Li Yang |
| Affiliation | 1.Shandong Laboratory of Yantai Advanced Materials and Green Manufacturing 2.Yantai Zhongke Research Institute of Advanced Materials and Green Chemical Engineering 3.CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS) 4.Department of Chemistry, College of Natural Sciences, Can Tho University |
| Recommended Citation GB/T 7714 | Jun Wang,Xian-Hua Meng,Wei-Feng Wang,et al. Dammarane Triterpenoids with Rare Skeletons from Gynostemma pentaphyllum and Their Cytotoxic Activities[J]. Fitoterapia,2022(162):105280. |
| APA | Jun Wang,Xian-Hua Meng,Wei-Feng Wang,Chun-Yan Sang,Thi-Kim-Quy Ha,&Jun-Li Yang.(2022).Dammarane Triterpenoids with Rare Skeletons from Gynostemma pentaphyllum and Their Cytotoxic Activities.Fitoterapia(162),105280. |
| MLA | Jun Wang,et al."Dammarane Triterpenoids with Rare Skeletons from Gynostemma pentaphyllum and Their Cytotoxic Activities".Fitoterapia .162(2022):105280. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| 2022 Fitoterapia-Dam（1089KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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