Dual-functional fluorescent probe responds to hypochlorous acid and SO2 derivatives with different fluorescence signals | |
Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Yu H(于辉)1,2; Wu, Yongna3; Hu Y(胡玥)1; Gao XD(高旭东)1; Liang Q(梁卿)1; Xu J(徐健)1; Shao SJ(邵士俊)1; Xu J(徐健); Shao SJ(邵士俊) | |
2017 | |
Source Publication | Talanta |
ISSN | 0039-9140 |
Volume | 165Pages:625-631 |
Abstract | In view of the important roles of reactive oxygen species (ROS) and reactive sulfur species (RSS) in the complex signal transduction and oxidation pathways, fluorescent probes that are able to display distinct signals to hypochlorous acid and SO2 derivatives are highly valuable. Herein, a novel dual-functional probe (DFP) as an efficient single fluorescent-molecule which can respond to HClO and HSO3− with two different sets of fluorescence signals was presented. The DFP displayed desired properties such as high specificity, suitable sensitivity, appreciable water solubility and stability. The sensing mechanism was confirmed by high-resolution mass spectroscopy analysis and 1H NMR spectrometry analysis. Moreover, as a biocompatible molecule, the DFP has been successfully applied for the detection of HClO in living cells with a dual-channel mode. Therefore, the present work established a novel strategy for monitoring the multiple ROS and RSS species using a single fluorescent probe and the DFP is promising as a molecular tool to investigate the production and dynamics of HClO and HSO3− in the complex interaction networks of the living system. |
Keyword | Dual-functional Probe Hypochlorous Acid So2 Derivatives Fluorescence Imaging |
Subject Area | 分析化学与药物化学 |
DOI | 10.1016/j.talanta.2017.01.015 |
Funding Organization | the National Natural Science Foundation of China (21572239;21505145;21275150);the Personnel Training Project of the West Light Foundation of the Chinese Academy of Sciences (2016, to Jian Xu);the top priority program of “One-Three-Five” Strategic Planning of Lanzhou Institute of Chemical Physics, CAS |
Indexed By | SCI |
If | 4.162 |
Language | 英语 |
Funding Project | 药物分子识别研究组;药物公共测试管理组 |
compositor | 第一作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/21527 |
Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Corresponding Author | Xu J(徐健); Shao SJ(邵士俊) |
Affiliation | 1.CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, P.R. China 2.University of Chinese Academy of Sciences, Beijing 100049, P.R. China 3.First Hospital of Lanzhou University, Lanzhou 730000, P.R. China |
Recommended Citation GB/T 7714 | Yu H,Wu, Yongna,Hu Y,et al. Dual-functional fluorescent probe responds to hypochlorous acid and SO2 derivatives with different fluorescence signals[J]. Talanta,2017,165:625-631. |
APA | Yu H.,Wu, Yongna.,Hu Y.,Gao XD.,Liang Q.,...&邵士俊.(2017).Dual-functional fluorescent probe responds to hypochlorous acid and SO2 derivatives with different fluorescence signals.Talanta,165,625-631. |
MLA | Yu H,et al."Dual-functional fluorescent probe responds to hypochlorous acid and SO2 derivatives with different fluorescence signals".Talanta 165(2017):625-631. |
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