| Preparation, characterization and drug-release behaviors of crosslinked chitosan/attapulgite hybrid microspheres by a facile spray-drying technique | |
| Department | 环境材料与生态化学研究发展中心 |
Wang Q(汪琴) ; Wu J(吴杰); Wang WB(王文波); Wang AQ(王爱勤); 王爱勤 aqwang@licp.cas.cn
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| 2011 | |
| Source Publication | Journal of Biomaterials and Nanobiotechnology
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| ISSN | 2158-7027 |
| Volume | 2Issue:3Pages:250-257 |
| Abstract | A series of chitosan/attapulgite (CTS/APT) hybrid microspheres were prepared by a facile spray-drying technique. The developed hybrid microspheres were characterized by Fourier transform infrared spectra (FTIR), X-ray powder diffraction (XRD), scanning electron microscopy (SEM) and the zeta potential. The encapsulation efficiency and in vitro controlled release properties of the microspheres for drug were evaluated using diclofenac sodium (DS) as a model drug. Results indicated that the introduction of APT into crosslinked CTS microspheres can achieve narrow size distribution and make them more uniform. The isoelectric point of the microspheres increased from 8.14 to 9.18 with increasing the content of APT to 10 wt%. DS loaded in hybrid microspheres is hardly released in simulated gastric fluid, but quickly released in simulated intestinal fluid. The electrostatic interaction between hybrid microspheres and DS can improve the encapsulation efficiency and controlled release behavior of CTS/APT microspheres, and the release mechanism fits Fickian diffusion. |
| Keyword | Microsphere Chitosan Attapulgite Spray Drying Controlled Release |
| Subject Area | 矿物学 |
| Funding Organization | 中科院院长奖获得者科研启动专项(2008-06) |
| Language | 英语 |
| Funding Project | 功能复合材料组 |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/93 |
| Collection | 环境材料与生态化学研究发展中心 |
| Corresponding Author | 王爱勤 aqwang@licp.cas.cn |
| Recommended Citation GB/T 7714 | Wang Q,Wu J,Wang WB,et al. Preparation, characterization and drug-release behaviors of crosslinked chitosan/attapulgite hybrid microspheres by a facile spray-drying technique[J]. Journal of Biomaterials and Nanobiotechnology,2011,2(3):250-257. |
| APA | 汪琴,吴杰,王文波,王爱勤,&王爱勤 aqwang@licp.cas.cn.(2011).Preparation, characterization and drug-release behaviors of crosslinked chitosan/attapulgite hybrid microspheres by a facile spray-drying technique.Journal of Biomaterials and Nanobiotechnology,2(3),250-257. |
| MLA | 汪琴,et al."Preparation, characterization and drug-release behaviors of crosslinked chitosan/attapulgite hybrid microspheres by a facile spray-drying technique".Journal of Biomaterials and Nanobiotechnology 2.3(2011):250-257. |
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| 201123250257.pdf（1066KB） | 开放获取 | License | View Application Full Text | |||
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