| Hemin-functionalized WS2 nanosheets as highly active peroxidase mimetics for label-free colorimetric detection of H2O2 and glucose | |
| Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Chen Q(陈桥)1,2; Chen J(陈佳)1 ; Gao, Cunji1; Zhang ML(张明亮)1; Chen JY(陈俊英)2; Qiu HD(邱洪灯)1; Qiu HD(邱洪灯)
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| 2015 | |
| Source Publication | Analyst
 |
| ISSN | 0003-2654 |
| Volume | 140Issue:8Pages:2857-2863 |
| Abstract | Hemin-functionalized WS2 nanosheets (hemin/WS2-NSs) were first obtained by hemin assembled on the surface of few-layered WS2 nanosheets (WS2-NSs) via van der Waals interactions. Significantly, this new material possessed the advantages of both hemin and WS2 nanosheets and exhibited some unique properties. Firstly, hemin/WS2-NSs had intrinsic peroxidase-like activity, which could effectively catalyze oxidation of the substrate 3,3’,5,5’-tetramethylbenzidine (TMB) by H2O2 to produce a typical blue colored reaction. Secondly, the activity of hemin/WS2-NSs was much higher than the activity of hemin or WS2-NSs alone. The catalytic activity followed the typical Michaelis–Menten kinetics and was dependent on the temperature, pH, H2O2 concentration, as well as reaction time. Based on this finding, a new highly sensitive and selective colorimetric method for H2O2 and glucose detection was developed. This method was simple and inexpensive for glucose detection using glucose oxidase (GOx) and hemin/WS2-NSs with a linear range of 0.5 × 10−5 to 2.0 × 10−4 mol L−1 with a detection limit of 1.5 × 10−6 mol L−1. The good catalytic activity and low-cost make the hemin/WS2-NSs a useful biocatalyst for a wide range of potential applications in environmental chemistry, biotechnology and clinical diagnostics. |
| Subject Area | 分析化学与药物化学 |
| DOI | 10.1039/c5an00031a |
| Funding Organization | the National Natural Science Foundation of China (no. 21405163; 21475142);the “Hundred Talents Program” of the Chinese Academy of Science;the Foundation for Sci&Tech Research Project of Gansu province (145RJYA271) |
| Indexed By | SCI |
| If | 4.033 |
| Language | 英语 |
| Funding Project | 药物分离材料研究组 |
| compositor | 第一作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/7217 |
| Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Corresponding Author | Qiu HD(邱洪灯) |
| Affiliation | 1.Chinese Acad Sci, Key Lab Chem Northwestern Plant Resources, Key Lab Nat Med Gansu Prov, Lanzhou Inst Chem Phys, Lanzhou 730000, Peoples R China 2.Southwest Jiaotong Univ, Minist Educ, Sch Mat Sci & Engn, Key Lab Adv Technol Mat, Chengdu 610031, Peoples R China |
| Recommended Citation GB/T 7714 | Chen Q,Chen J,Gao, Cunji,et al. Hemin-functionalized WS2 nanosheets as highly active peroxidase mimetics for label-free colorimetric detection of H2O2 and glucose[J]. Analyst,2015,140(8):2857-2863. |
| APA | Chen Q.,Chen J.,Gao, Cunji.,Zhang ML.,Chen JY.,...&邱洪灯.(2015).Hemin-functionalized WS2 nanosheets as highly active peroxidase mimetics for label-free colorimetric detection of H2O2 and glucose.Analyst,140(8),2857-2863. |
| MLA | Chen Q,et al."Hemin-functionalized WS2 nanosheets as highly active peroxidase mimetics for label-free colorimetric detection of H2O2 and glucose".Analyst 140.8(2015):2857-2863. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| 2015-Analyst-Chen.PD（1223KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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