Simultaneous Determination of Anthraquinone Derivatives in Radix et Rhizoma Rhei-based Medicines by Ultra-Performance LC-ESCI-MS/MS Multiple Reaction Monitoring | |
Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Wang GY(王国英)1,2,3; Shi YP(师彦平)1,2; Shi YP(师彦平) | |
2014 | |
Source Publication | Acta Chromatographica |
ISSN | 1233-2356 |
Volume | 26Issue:2Pages:229-242 |
Abstract | A new method using ultra-performance liquid chromatography (UPLC) in combination with tandem mass spectrometry and a multiple reaction monitoring mode (UPLC-MS/MS-MRM) was developed for simultaneous quantitative determination of anthraquinone derivatives in Radix et Rhizoma Rhei-based medicines. A multi-mode electrospray/chemical ionization (ESCI) and negative ion mode with [M-H]− and its fragments under collision-activated conditions were employed in MS/MS-MRM. The quantitative method was validated and applied to simultaneous determination of anthraquinone derivatives in 21 Radix et Rhizoma Rhei-based medicines. The limits of quantification were in the range of 3.90–9.09 ng mL−1. Average recoveries were between 95.5% and 99.8% with relative standard deviations from 1.8% to 5.3%. |
Keyword | Ultra-performance Lc Tandem Mass Spectrometry Multiple Reaction Monitoring Anthraquinone Derivatives Radix Et Rhizoma Rhei-based Medicines |
Subject Area | 分析化学与药物化学 |
DOI | 10.1556/AChrom.26.2014.2.3 |
Funding Organization | the National Key Technology Research and Development Program of China (no. 2007BAI37B05);the Western high-tech Project Action Plan of Chinese Academy of Sciences (no. KG-CX2-YW-510) |
Indexed By | SCI |
If | 0.577 |
Language | 英语 |
Funding Project | 药物化学成分研究组 |
compositor | 第一作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/6951 |
Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Corresponding Author | Shi YP(师彦平) |
Affiliation | 1.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China 3.Lanzhou Univ Technol, Sch Petr & Chem Engn, Lanzhou 730050, Peoples R China |
Recommended Citation GB/T 7714 | Wang GY,Shi YP,Shi YP. Simultaneous Determination of Anthraquinone Derivatives in Radix et Rhizoma Rhei-based Medicines by Ultra-Performance LC-ESCI-MS/MS Multiple Reaction Monitoring[J]. Acta Chromatographica,2014,26(2):229-242. |
APA | Wang GY,Shi YP,&师彦平.(2014).Simultaneous Determination of Anthraquinone Derivatives in Radix et Rhizoma Rhei-based Medicines by Ultra-Performance LC-ESCI-MS/MS Multiple Reaction Monitoring.Acta Chromatographica,26(2),229-242. |
MLA | Wang GY,et al."Simultaneous Determination of Anthraquinone Derivatives in Radix et Rhizoma Rhei-based Medicines by Ultra-Performance LC-ESCI-MS/MS Multiple Reaction Monitoring".Acta Chromatographica 26.2(2014):229-242. |
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AChrom-2014(WangGY).(172KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text |
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