In vitro anti-inflammatory effects of diterpenoids and sesquiterpenoids from traditional Chinese medicine Siegesbeckia pubescens | |
Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Wang R(王瑞)1; Liu YQ(刘映前)2; Ha W(哈伟)3; Shi YP(师彦平)3; Tsong-Long Hwang4; Guan-Jhong Huang5; Wu, Tian-Shung6; Kuo-Hsiung Lee7,8; Shi YP(师彦平) | |
2014 | |
Source Publication | Bioorganic & Medicinal Chemistry Letters |
ISSN | 0960-894X |
Volume | 24Issue:16Pages:3944-3947 |
Abstract | Oxidative stress imposed by reactive oxygen species plays a crucial role in pathophysiology of inflammatory diseases. In the present study, sesquiterpenoids and diterpenoids isolated from Siegesbeckia pubescens, a Chinese traditional medicine used to treat arthritis, were evaluated for inhibition of NO production in activated RAW 264.7 macrophages and FMLP/CB induced O2- generation and elastase release in human neutrophils. In the former assay, sesquiterpenoids were more potent than diterpenoids. The C-4 carbonyl group in the carabrane-type sesquiterpenoid 3 and the C-9 ether linkage in the germacrane sesquiterpene 7 were associated with the enhanced potency. Also, for the active ent-kaurane type diterpenoids, esterification of 17-OH with isobutyric acid and acetylation of 18-OH affected the inhibition of O2- generation and elastase release. This report is the first to describe the inhibitory effects on oxidative stress of secondary metabolites from S. pubescens. Its findings suggest that active terpenoids from the herb could be used as lead anti-inflammatory agents. |
Keyword | Anti-inflammatory Siegesbeckia Pubescens No Production O-2(-) Generation Elastase Release Cytotoxicity |
Subject Area | 分析化学与药物化学 |
DOI | 10.1016/j.bmcl.2014.06.039 |
Funding Organization | the National Natural Science Foundation of China (NSFC 81303202;21375136) |
Indexed By | SCI |
If | 2.420 |
Language | 英语 |
Funding Project | 药物化学成分研究组 |
compositor | 第三作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/6935 |
Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Corresponding Author | Kuo-Hsiung Lee; Shi YP(师彦平) |
Affiliation | 1.Key Laboratory of Biochemistry and Molecular Biology in Universities of Shandong Province, Weifang University, Weifang 261061, PR China 2.School of Pharmacy, Lanzhou University, Lanzhou 730000, PR China 3.Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, PR China 4.Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan 5.School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 404, Taiwan 6.Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan 7.Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7568, United States 8.Chinese Medicine Research and Development Center, China Medical University and Hospital, Taichung, Taiwan |
Recommended Citation GB/T 7714 | Wang R,Liu YQ,Ha W,et al. In vitro anti-inflammatory effects of diterpenoids and sesquiterpenoids from traditional Chinese medicine Siegesbeckia pubescens[J]. Bioorganic & Medicinal Chemistry Letters,2014,24(16):3944-3947. |
APA | Wang R.,Liu YQ.,Ha W.,Shi YP.,Tsong-Long Hwang.,...&师彦平.(2014).In vitro anti-inflammatory effects of diterpenoids and sesquiterpenoids from traditional Chinese medicine Siegesbeckia pubescens.Bioorganic & Medicinal Chemistry Letters,24(16),3944-3947. |
MLA | Wang R,et al."In vitro anti-inflammatory effects of diterpenoids and sesquiterpenoids from traditional Chinese medicine Siegesbeckia pubescens".Bioorganic & Medicinal Chemistry Letters 24.16(2014):3944-3947. |
Files in This Item: | ||||||
File Name/Size | DocType | Version | Access | License | ||
BMCL-2014(WangR).pdf(379KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text |
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment