| Freeze-drying: A versatile method to overcome re-aggregation and improve dispersion stability of palygorskite for sustained release of ofloxacin | |
| Department | 环境材料与生态化学研究发展中心 |
Wang Q(汪琴)1,2 ; Zhang JP(张俊平)1; Wang AQ(王爱勤)1,2; Zhang JP(张俊平)
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| 2014 | |
| Source Publication | Applied Clay Science
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| ISSN | 0169-1317 |
| Volume | 87Issue:1Pages:7-13 |
| Abstract | In order to overcome the re-aggregation of palygorskite nanofibers in the drying process, the palygorskite clay was freeze-dried instead of the traditional oven-drying after disaggregated by high-pressure homogenization. The effects of freeze-drying temperature on the microstructure and physicochemical properties of palygorskite clay were investigated by SEM, FTIR and BET. Further, the dispersion stability and rheological properties of the freeze-dried palygorskite clay as well as its adsorption and in vitro release properties for ofloxacin were studied. The results showed that the re-aggregation of palygorskite nanofibers can be successfully overcome by freeze-drying. Meanwhile, the structure and aspect ratio of palygorskite nanofibers were kept very well. Consequently, the dispersion stability and apparent viscosity of palygorskite in deionized water were enhanced compared with the traditional oven-dried sample. In addition, the freeze-drying of palygorskite induced more of the adsorbed ofloxacin to be released within 24 h although no evident increase in adsorption capacity was observed. This means that the adsorbed ofloxacin molecules remained active and most of them could be released from the freeze-dried palygorskite, which is very important for a drug delivery vehicle. Moreover, the physicochemical properties of palygorskite and the cumulative release of ofloxacin could be tuned by the freeze-drying temperature according to practical applications. |
| Keyword | Palygorskite Freeze-drying Dispersion Stability Adsorption Capacity Release Property |
| Subject Area | 环境材料与生态化学 |
| DOI | 10.1016/j.clay.2013.11.017 |
| Funding Organization | the “National Natural Science Foundation of China” (no. 51003112);the “Top Hundred Talents Program of the Chinese Academy of Sciences”;the “Science and Technology Support Project of Jiangsu Provincial Sci. & Tech. Department” (no. BY2010012);the “Foundation of Key Laboratory for Palygorskite Science and Applied Technology of Jiangsu Province” (no. HPK201001) |
| Indexed By | SCI |
| If | 2.467 |
| Language | 英语 |
| Funding Project | 功能复合材料组 |
| compositor | 第一作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/6868 |
| Collection | 环境材料与生态化学研究发展中心 |
| Corresponding Author | Zhang JP(张俊平) |
| Affiliation | 1.Chinese Acad Sci, Ctr Ecomat & Green Chem, Lanzhou Inst Chem Phys, Lanzhou 730000, Peoples R China 2.Huaiyin Inst Technol, Key Lab Palygorskite Sci & Appl Technol Jiangsu P, Huaian 223003, Peoples R China |
| Recommended Citation GB/T 7714 | Wang Q,Zhang JP,Wang AQ,et al. Freeze-drying: A versatile method to overcome re-aggregation and improve dispersion stability of palygorskite for sustained release of ofloxacin[J]. Applied Clay Science,2014,87(1):7-13. |
| APA | Wang Q,Zhang JP,Wang AQ,&张俊平.(2014).Freeze-drying: A versatile method to overcome re-aggregation and improve dispersion stability of palygorskite for sustained release of ofloxacin.Applied Clay Science,87(1),7-13. |
| MLA | Wang Q,et al."Freeze-drying: A versatile method to overcome re-aggregation and improve dispersion stability of palygorskite for sustained release of ofloxacin".Applied Clay Science 87.1(2014):7-13. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| Freeze-drying-APT.pd（425KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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