| Facile preparation of magnetic 2-hydroxypropyltrimethyl ammonium chloride chitosan/Fe3O4/halloysite nanotubes microspheres for the controlled release of ofloxacin | |
| Department | 环境材料与生态化学研究发展中心 |
Wang Q(汪琴) ; Zhang JP(张俊平); Mu B(牟斌); Fan L(范玲); Wang AQ(王爱勤); Zhang JP(张俊平)
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| 2014 | |
| Source Publication | Carbohydrate Polymers
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| ISSN | 0144-8617 |
| Volume | 102Issue:2Pages:877-883 |
| Abstract | Magnetic microspheres, 2-hydroxypropyltrimethyl ammonium chloride chitosan/Fe3O4/halloysite nanotubes/ofloxacin (HACC/Fe3O4/HNTs/OFL), for the controlled release of OFL were prepared by in situ crosslinking with glutaraldehyde in the spray-drying process. The magnetic microspheres were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, thermogravimetric analysis and a magnetometer. Various parameters influencing the encapsulation efficiency, drug loading and in vitro controlled release properties of the magnetic microspheres for OFL were also studied. Many stripes were formed and some tubular HNTs could be seen at higher magnification on the surface of the HACC/Fe3O4/HNTs/OFL magnetic microspheres. The magnetic microspheres show superparamagnetic property and fast magnetic response. The encapsulation efficiency and the cumulative release of OFL are closely related to HACC concentration, HNTs contents and crosslinking density. The release of OFL follows the first-order kinetics. |
| Keyword | Quaternized Chitosan Halloysite Spray Drying Magnetic Microspheres Controlled Release |
| Subject Area | 环境材料与生态化学 |
| DOI | 10.1016/j.carbpol.2013.10.071 |
| Funding Organization | the National Natural Science Foundation of China (No. 51003112);the “Hundred Talents Program” of the Chinese Academy of Sciences |
| Indexed By | SCI |
| If | 4.074 |
| Language | 英语 |
| Funding Project | 功能复合材料组 |
| compositor | 第一作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/6867 |
| Collection | 环境材料与生态化学研究发展中心 |
| Corresponding Author | Zhang JP(张俊平) |
| Affiliation | Chinese Acad Sci, Lanzhou Inst Chem Phys, Ctr Ecomat & Green Chem, Lanzhou 730000, Peoples R China |
| Recommended Citation GB/T 7714 | Wang Q,Zhang JP,Mu B,et al. Facile preparation of magnetic 2-hydroxypropyltrimethyl ammonium chloride chitosan/Fe3O4/halloysite nanotubes microspheres for the controlled release of ofloxacin[J]. Carbohydrate Polymers,2014,102(2):877-883. |
| APA | Wang Q,Zhang JP,Mu B,Fan L,Wang AQ,&张俊平.(2014).Facile preparation of magnetic 2-hydroxypropyltrimethyl ammonium chloride chitosan/Fe3O4/halloysite nanotubes microspheres for the controlled release of ofloxacin.Carbohydrate Polymers,102(2),877-883. |
| MLA | Wang Q,et al."Facile preparation of magnetic 2-hydroxypropyltrimethyl ammonium chloride chitosan/Fe3O4/halloysite nanotubes microspheres for the controlled release of ofloxacin".Carbohydrate Polymers 102.2(2014):877-883. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| HACC-Fe3O4-HNTS-OFL.（2407KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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