| Charged Polymer Brushes-Grafted Hollow Silica Nanoparticles as a Novel Promising Material for Simultaneous Joint Lubrication and Treatment | |
| Department | 固体润滑国家重点实验室 |
Liu GQ(刘国强)1,2 ; Cai MR(蔡美荣)1; Zhou F(周峰)1; Liu WM(刘维民)1; Cai MR(蔡美荣); Zhou F(周峰)
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| 2014 | |
| Source Publication | Journal of Physical Chemistry B
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| ISSN | 1520-6106 |
| Volume | 118Issue:18Pages:4920-4931 |
| Abstract | The fabrication of core/shell charged polymer brushes-grafted hollow silica nanoparticles (PSPMA-g-HSNPs) is reported. Because of the excellent hydration capability of the shells consisting of charged polymer brushes, the functional nanoparticles can achieve a good lubricating effect in aqueous media via hydration lubrication mechanism. The mesoporous hollow silica cores endow the nanoparticles with drug loading-release capability. Aspirin, as a useful drug for treating arthritis, was employed to carry out in vitro drug loading and release studies. It is clear that brushes-modified hollow silica exhibited long-term drug release performance. The combination of lubrication and drug loading capabilities results in the great clinical potential of new multifunctional nanoparticles as injectable joint lubricant fluid in arthritis treatment. |
| Subject Area | 材料科学与物理化学 |
| DOI | 10.1021/jp500074g |
| Funding Organization | NSFC (21125316;21204095;51335010);973 projects (2013CB632300);Key Research Program of CAS (KJZD-EW-M01) |
| Indexed By | SCI |
| If | 3.302 |
| Language | 英语 |
| Funding Project | 材料表面与界面行为研究组;空间润滑材料组 |
| compositor | 第一作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/6841 |
| Collection | 固体润滑国家重点实验室（LSL） |
| Corresponding Author | Cai MR(蔡美荣); Zhou F(周峰) |
| Affiliation | 1.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Solid Lubricat, Lanzhou 730000, Gansu, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| Recommended Citation GB/T 7714 | Liu GQ,Cai MR,Zhou F,et al. Charged Polymer Brushes-Grafted Hollow Silica Nanoparticles as a Novel Promising Material for Simultaneous Joint Lubrication and Treatment[J]. Journal of Physical Chemistry B,2014,118(18):4920-4931. |
| APA | Liu GQ,Cai MR,Zhou F,Liu WM,蔡美荣,&周峰.(2014).Charged Polymer Brushes-Grafted Hollow Silica Nanoparticles as a Novel Promising Material for Simultaneous Joint Lubrication and Treatment.Journal of Physical Chemistry B,118(18),4920-4931. |
| MLA | Liu GQ,et al."Charged Polymer Brushes-Grafted Hollow Silica Nanoparticles as a Novel Promising Material for Simultaneous Joint Lubrication and Treatment".Journal of Physical Chemistry B 118.18(2014):4920-4931. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| J. Phys. Chem. B 201（5747KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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