| Iron-catalyzed Michael reactions revisited: a synthetically useful process for the preparation of tri-carbonyl compounds and chiral warfarin | |
| Department | 羰基合成与选择氧化国家重点实验室 |
Yang HM(杨化萌); Gao YH(高月华); Li L(李莉); Jiang ZY(姜振钰); Lai GQ(来国桥); Xia CG(夏春谷) ; Xu LW(徐利文)
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| 2010 | |
| Source Publication | Tetrahedron Lett.
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| ISSN | 0040-4039 |
| Volume | 51Pages:3836-3839 |
| Abstract | The LBAs (Lewis acid-assisted Brønsted acid catalysis) is proposed as possible mechanistic process in the simple FeCl3-catalyzed Michael reactions of chalcones with active methylene compounds in organic solvents. And iron salts were found to be effective promoters in the asymmetric Michael addition of 4-hydroxycoumarin to a,b-unsaturated ketone, which resulted in excellent yield and high level of enantioselectivity (up to 91% ee) in the presence of low catalytic amount of iron and simple chiral primary amine. |
| Keyword | Iron Catalysis Michael Reaction Warfarin Asymmetric Catalysis Primary Amine |
| Subject Area | 物理化学 |
| Funding Organization | the National Natural Science Founder of China (No. 20973051);Zhejiang Provincial Natural Science Foundation of China (Y4090139) |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | 清洁催化与生物转化研究组 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/497 |
| Collection | 羰基合成与选择氧化国家重点实验室（OSSO） |
| Corresponding Author | Xu LW(徐利文) |
| Recommended Citation GB/T 7714 | Yang HM,Gao YH,Li L,et al. Iron-catalyzed Michael reactions revisited: a synthetically useful process for the preparation of tri-carbonyl compounds and chiral warfarin[J]. Tetrahedron Lett.,2010,51:3836-3839. |
| APA | 杨化萌.,高月华.,李莉.,姜振钰.,来国桥.,...&徐利文.(2010).Iron-catalyzed Michael reactions revisited: a synthetically useful process for the preparation of tri-carbonyl compounds and chiral warfarin.Tetrahedron Lett.,51,3836-3839. |
| MLA | 杨化萌,et al."Iron-catalyzed Michael reactions revisited: a synthetically useful process for the preparation of tri-carbonyl compounds and chiral warfarin".Tetrahedron Lett. 51(2010):3836-3839. |
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| 4B_Tetrahedron Lett.（575KB） | 开放获取 | License | View Application Full Text | |||
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