| Structural and Mechanistic Bases of the Anticancer Activity of Natural Aporphinoid Alkaloids | |
| Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Liu YJ(刘言娟)1,2,3 ; Liu JX(柳军玺)1,2; Di DL(邸多隆)1,2; Li M(李敏)4; Feng Y(冯艳)5; Liu JX(柳军玺); Di DL(邸多隆)
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| 2013 | |
| Source Publication | Current Topics in Medicinal Chemistry
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| ISSN | 1568-0266 |
| Volume | 13Issue:17Pages:2116-2126 |
| Abstract | Aporphinoid alkaloids, which encompass a large number of complicated structures, are an important group of natural products. The anticancer activity of aporphinoid alkaloids has become a hot pharmaceutical research area in recent years. Recent studies on the anticancer activity of these compounds are reviewed. The structure activity relationships (SARs) and anticancer mechanisms of aporphinoid alkaloids, as well as simple aporphine, oxoaporphine, dehydroaporphine and dimeric aporphine, have been summarized. The presence of a 1,2-methylenedioxy group and methylation of nitrogen are key features to the cytotoxicity of aporphinoid alkaloids. Oxidation and dehydrogenation of C7 could improve the anticancer activity. The contributions of chirality of hydrogen at C6a and the substitution pattern of other positions about aporphinoid alkaloids for anticancer activity remain unknown. Induced cancer cells apoptosis, prevention of cell proliferation, DNA topoisomerase inhibition, reducing the drug-resistant cellular side population (SP) or cancer stem cells (CSCs) and inhibition of epidermal growth factor receptor (EGFR) tyrosine kinase seem to play important roles in the molecular mechanisms of anticancer activity about aporphinoid alkaloids. |
| Keyword | Natural Product Aporphinoid Alkaloids Chemical Structure Anticancer Activity Apoptosis Sars |
| Subject Area | 分析化学与药物化学 |
| Funding Organization | “The light of western of Chinese academy of sciences”;the science and technology program of Gansu (090NKCA127);the national natural sciences foundation of China (NSFC 20974116) |
| Indexed By | SCI |
| If | 3.453 |
| Language | 英语 |
| Funding Project | 药物工艺标准研究组 |
| compositor | 第一作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/4899 |
| Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Corresponding Author | Liu JX(柳军玺); Di DL(邸多隆) |
| Affiliation | 1.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 4.Lanzhou Univ Technol, Coll Petrochem Engn, Lanzhou 730000, Peoples R China 5.Lanzhou Univ Technol, Coll Life Sci & Engn, Lanzhou 730000, Peoples R China |
| Recommended Citation GB/T 7714 | Liu YJ,Liu JX,Di DL,et al. Structural and Mechanistic Bases of the Anticancer Activity of Natural Aporphinoid Alkaloids[J]. Current Topics in Medicinal Chemistry,2013,13(17):2116-2126. |
| APA | Liu YJ.,Liu JX.,Di DL.,Li M.,Feng Y.,...&邸多隆.(2013).Structural and Mechanistic Bases of the Anticancer Activity of Natural Aporphinoid Alkaloids.Current Topics in Medicinal Chemistry,13(17),2116-2126. |
| MLA | Liu YJ,et al."Structural and Mechanistic Bases of the Anticancer Activity of Natural Aporphinoid Alkaloids".Current Topics in Medicinal Chemistry 13.17(2013):2116-2126. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| 刘言娟.pdf（323KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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