| Palladium-Catalyzed C-H Activation/Cross-Coupling of Pyridine N-Oxides with Nonactivated Secondary Alkyl Bromides | |
| Department | OSSO国家重点实验室 |
| Xiao B(肖斌)1,2,3; Liu ZJ(刘照静)1; Liu L(刘磊)2,3; Fu Y(傅尧)1; Fu Y(傅尧) | |
| 2013 | |
| Source Publication | Journal of the American Chemical Society
 |
| ISSN | 0002-7863 |
| Volume | 135Issue:2Pages:616-619 |
| Abstract | An unexpected C-H activation/C-C cross-coupling reaction has been found to occur between pyridine N-oxides and general nonactivated secondary and even tertiary alkyl bromides. It provides a practically useful approach for the synthesis of alkylated pyridine derivatives. Experimental observations indicated that the C-Br cleavage step involves a radical-type process. Thus, the title reaction provides a rather extraordinary example of Pd-catalyzed cross-coupling of secondary and tertiary aliphatic electrophiles. |
| Subject Area | 物理化学与绿色催化 |
| DOI | 10.1021/ja3113752 |
| Funding Organization | the 973 Program (2013CB932800);the NNSFC (20972148);CAS (KJCX2-EW-J02);the China Postdoctoral Science Foundation (2011M500289;2012T50078) |
| Indexed By | SCI |
| If | 11.444 |
| Language | 英语 |
| compositor | 第三作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/4885 |
| Collection | 羰基合成与选择氧化国家重点实验室（OSSO） |
| Corresponding Author | Fu Y(傅尧) |
| Affiliation | 1.Univ Sci & Technol China, Dept Chem, Hefei 230026, Peoples R China 2.Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China 3.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China |
| Recommended Citation GB/T 7714 | Xiao B,Liu ZJ,Liu L,et al. Palladium-Catalyzed C-H Activation/Cross-Coupling of Pyridine N-Oxides with Nonactivated Secondary Alkyl Bromides[J]. Journal of the American Chemical Society,2013,135(2):616-619. |
| APA | Xiao B,Liu ZJ,Liu L,Fu Y,&傅尧.(2013).Palladium-Catalyzed C-H Activation/Cross-Coupling of Pyridine N-Oxides with Nonactivated Secondary Alkyl Bromides.Journal of the American Chemical Society,135(2),616-619. |
| MLA | Xiao B,et al."Palladium-Catalyzed C-H Activation/Cross-Coupling of Pyridine N-Oxides with Nonactivated Secondary Alkyl Bromides".Journal of the American Chemical Society 135.2(2013):616-619. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| J. Am. Chem. Soc., 2（398KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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