| A Sulfonic-Azobenzene-Grafted Silica Amphiphilic Material: A Versatile Stationary Phase for Mixed-Mode Chromatography | |
| Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Qiu HD(邱洪灯)1,2 ; Zhang ML(张明亮)1,2; Gu TN(顾桐年)1,2; Takafuji, Makoto3; Ihara, Hirotaka3; Qiu HD(邱洪灯); Hirotaka Ihara
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| 2013 | |
| Source Publication | Chemistry - A European Journal
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| ISSN | 0947-6539 |
| Volume | 19Issue:52Pages:18004-18010 |
| Abstract | A novel sulfonic-azobenzene-functionalized amphiphilic silica material was synthesized through the preparation of a new sulfonic azobenzene monomer and its grafting on mercaptopropyl-modified silica by a surface-initiated radical chain-transfer reaction. The synthesis was confirmed by infrared spectra, elemental analysis, and thermogravimetric analysis. This new material was successfully applied as a new kind of mixed-mode stationary phase in liquid chromatography. This allows an exceptionally flexible adjustment of retention and selectivity by tuning the experimental conditions. The distinct separation mechanisms were outlined by selected examples of chromatographic separations in the different modes. In reversed-phase liquid chromatography, this new stationary phase presented specific chromatographic performance when evaluated using a Tanaka test mixture. Seven dinitro aromatic isomers, four steroids, and seven flavonoids were separated successfully in simple reversed-phase mode. This stationary phase can also be used in hydrophilic interaction chromatography because of the existing polar functional groups; for this, nucleosides and their bases were used as a test mixture. Interestingly, the same nucleosides and bases can also be separated in per aqueous liquid chromatography using the same stationary phase. Three ginsenosides including Rg1, Re, and Rb1 were successfully separated in hydrophilic mode. There is the potential for more applications to benefit from this useful column. |
| Keyword | Amphiphiles Analytical Methods Azo Compounds Liquid Chromatography Silica |
| Subject Area | 分析化学与药物化学 |
| DOI | 10.1002/chem.201302746 |
| Funding Organization | the “Hundred Talents Program” of Chinese Academy of Science;the Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan;Grant-in-Aid for Program for Fostering Regional Innovation |
| Indexed By | SCI |
| If | 5.696 |
| Language | 英语 |
| Funding Project | 药物分离材料研究组 |
| compositor | 第一作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/4881 |
| Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Corresponding Author | Qiu HD(邱洪灯); Hirotaka Ihara |
| Affiliation | 1.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China 3.Kumamoto Univ, Dept Appl Chem & Biochem, Kumamoto 8608555, Japan |
| Recommended Citation GB/T 7714 | Qiu HD,Zhang ML,Gu TN,et al. A Sulfonic-Azobenzene-Grafted Silica Amphiphilic Material: A Versatile Stationary Phase for Mixed-Mode Chromatography[J]. Chemistry - A European Journal,2013,19(52):18004-18010. |
| APA | Qiu HD.,Zhang ML.,Gu TN.,Takafuji, Makoto.,Ihara, Hirotaka.,...&Hirotaka Ihara.(2013).A Sulfonic-Azobenzene-Grafted Silica Amphiphilic Material: A Versatile Stationary Phase for Mixed-Mode Chromatography.Chemistry - A European Journal,19(52),18004-18010. |
| MLA | Qiu HD,et al."A Sulfonic-Azobenzene-Grafted Silica Amphiphilic Material: A Versatile Stationary Phase for Mixed-Mode Chromatography".Chemistry - A European Journal 19.52(2013):18004-18010. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| CEJ-2013-.pdf（357KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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