One-shot indole-to-carbazole pi-extension by a Pd-Cu-Ag trimetallic system | |
Department | OSSO国家重点实验室 |
Ozaki, Kyohei1; Zhang H(张华)2; Ito, Hideto1; Lei AW(雷爱文)2,3; Itami, Kenichiro1,4; Lei AW(雷爱文) | |
2013 | |
Source Publication | Chemical Science |
ISSN | 2041-6520 |
Volume | 4Issue:9Pages:3416-3420 |
Abstract | We have developed a Pd-Cu-Ag trimetallic system that can convert indoles to carbazoles using electron-deficient alkenes as two-carbon units. Investigation of the reaction mechanism revealed that this one-shot indole-to-carbazole pi-extension is likely to proceed through the sequence of (i) Pd/Cu-catalyzed indole C-H alkenylation, (ii) Ag-promoted Diels-Alder reaction and dehydrogenative aromatization. The successful one-pot synthesis of a granulatimide derivative, an interesting class of Chk1 kinase inhibitor, highlights the potential of the present reaction for further development and applications. |
Subject Area | 物理化学与绿色催化 |
DOI | 10.1039/c3sc51447a |
Funding Organization | the Funding Program for Next Generation World-Leading Researchers from JSPS (220GR049 to K.I.) H.I;JSPS for a postdoctoral fellowship |
Indexed By | SCI |
If | 8.601 |
Language | 英语 |
compositor | 第三作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/4858 |
Collection | 羰基合成与选择氧化国家重点实验室(OSSO) |
Corresponding Author | Itami, Kenichiro; Lei AW(雷爱文) |
Affiliation | 1.Nagoya Univ, Grad Sch Sci, Dept Chem, Chikusa Ku, Nagoya, Aichi 4648602, Japan 2.Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Hubei, Peoples R China 3.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China 4.Nagoya Univ, Inst Transformat Biomol WPI ITbM, Chikusa Ku, Nagoya, Aichi 4648602, Japan |
Recommended Citation GB/T 7714 | Ozaki, Kyohei,Zhang H,Ito, Hideto,et al. One-shot indole-to-carbazole pi-extension by a Pd-Cu-Ag trimetallic system[J]. Chemical Science,2013,4(9):3416-3420. |
APA | Ozaki, Kyohei,Zhang H,Ito, Hideto,Lei AW,Itami, Kenichiro,&雷爱文.(2013).One-shot indole-to-carbazole pi-extension by a Pd-Cu-Ag trimetallic system.Chemical Science,4(9),3416-3420. |
MLA | Ozaki, Kyohei,et al."One-shot indole-to-carbazole pi-extension by a Pd-Cu-Ag trimetallic system".Chemical Science 4.9(2013):3416-3420. |
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Chem. Sci., 2013,4, (855KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text |
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