| Preparation and characterization of SiO2/SiO2 core-shell microspheres as RP-HPLC stationary phase | |
| Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Liu Q(刘芹); Wang LT(王利涛) ; Dong SQ(董树清); Zhang ZX(张志欣); Zhao L(赵亮); Zhao L(赵亮)
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| 2011 | |
| Conference Name | 第一届先进材料国际会议 |
| Funding Organization | 国际先进材料联合会 |
| Conference Date | 2011-5-13 |
| Conference Place | 山东济南 |
| Abstract |
Novel SiO2/SiO2 core-shell monodisperse silica spheres for high performance liquid chromatography (HPLC) packing materials are prepared by the layer-by-layer self-assembly technique. The core-shell silica spheres consist of micrometer-sized porous silica spheres as core and a thin mesoporous silica shell formed from multilayer nanometer-sized silica particles. In addition, a reversed-phase packing by bonding octadecyltrichlorosilane on SiO2/SiO2 particles through alkyl modified method is prepared and characterized. The results show that the carbon content of the new reversed-phase stationary phase increases approximately by 45% compared with the uncoated octadecyl-bonded SiO2 stationary phase. Eight kinds of tested aromatic compounds are wellseparated on the packing and the peaks are symmetrical, which demonstrate that the packing acts as a truely reversed-phase chromatographic stationary phase. |
| Keyword | Layer-by-layer Self-assemble Hplc Packing Material Octadecyl-bonded Sio2/sio2 Stationary Phase |
| Subject Area | 分析化学与药物化学 |
| Funding Project | 药物手性分离研究组 |
| Language | 英语 |
| WOS ID | WOS:000297620800039 |
| Citation statistics | |
| Document Type | 会议论文 |
| Identifier | http://ir.licp.cn/handle/362003/4785 |
| Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Corresponding Author | Zhao L(赵亮) |
| Recommended Citation GB/T 7714 | Liu Q,Wang LT,Dong SQ,et al. Preparation and characterization of SiO2/SiO2 core-shell microspheres as RP-HPLC stationary phase[C],2011. |
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