| Measurement of acid dissociation constants and ionic mobilities of 3-nitro-tyrosine and 3-chloro-tyrosine by capillary zone electrophoresis | |
| Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Ren HX(任海霞)1,2 ; Wang LC(王立成)1; Wang XS(王旭生)1; Liu X(刘霞)1; Jiang SX(蒋生祥)1; Jiang SX(蒋生祥)
| |
| 2013 | |
| Source Publication | Journal of Pharmaceutical and Biomedical Analysis
 |
| ISSN | 0731-7085 |
| Volume | 77Pages:83-87 |
| Abstract | The ionization constant (pKa) and limiting ionic mobility of 3-chlorotyrosine (CT) and 3-nitrotyrosine (NT) were determined in capillary zone electrophoresis (CZE) in a wide pH range. Measurements were carried out in a poly(ionic liquid) (PIL) modified capillary at a low pH (1.80–4.00) and a bare fused capillary at an upper pH (3.00–11.00). Electrostatic interaction between analytes and inner wall was suppressed dramatically. Furthermore, parameters usually empirically assumed were calculated from a simple theoretical model. Besides pKa and limiting ionic mobility, diameter of the hydrated ion was calculated as well. The former were inserted into the database of Peakmaster software, whose predictions led to satisfactory agreement with experimental runs. |
| Keyword | Absolute Ionic Mobility Acidity Constant Amino Acid Cationic Coating Hydrodynamic Radius |
| Subject Area | 分析化学与药物化学 |
| DOI | 10.1016/j.jpba.2013.01.015 |
| Funding Organization | Natural Science Foundation of Gansu Province, China (No. 0803RJZ017);the National Science Foundation of China (Nos. 21175143;201105107) |
| Indexed By | SCI |
| If | 2.829 |
| Language | 英语 |
| Funding Project | 药物分离材料研究组 |
| compositor | 第一作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/4620 |
| Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Corresponding Author | Jiang SX(蒋生祥) |
| Affiliation | 1.Chinese Acad Sci, Lanzhou Inst Chem Phys, CAS Key Lab Nat Med Gansu Prov, Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Ren HX,Wang LC,Wang XS,et al. Measurement of acid dissociation constants and ionic mobilities of 3-nitro-tyrosine and 3-chloro-tyrosine by capillary zone electrophoresis[J]. Journal of Pharmaceutical and Biomedical Analysis,2013,77:83-87. |
| APA | Ren HX,Wang LC,Wang XS,Liu X,Jiang SX,&蒋生祥.(2013).Measurement of acid dissociation constants and ionic mobilities of 3-nitro-tyrosine and 3-chloro-tyrosine by capillary zone electrophoresis.Journal of Pharmaceutical and Biomedical Analysis,77,83-87. |
| MLA | Ren HX,et al."Measurement of acid dissociation constants and ionic mobilities of 3-nitro-tyrosine and 3-chloro-tyrosine by capillary zone electrophoresis".Journal of Pharmaceutical and Biomedical Analysis 77(2013):83-87. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| 任海霞-3.pdf（369KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment