| Casein Phosphopeptide-Biofunctionalized Graphene Biocomposite for Hydroxyapatite Biomimetic Mineralization | |
| Department | 固体润滑国家重点实验室 |
Fan ZJ(范增杰)1,2; Wang JQ(王金清)1 ; Wang ZF(王赵峰)1; Li ZP(李章朋)1; Qiu YN(邱宜农)3; Wang HG(王宏刚)1; Xu Y(许晔)1,2; Niu LY(牛棱渊)1,2; Gong PW(公培伟)1,2; Yang SR(杨生荣)1; Wang JQ(王金清); Yang SR(杨生荣)
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| The second department | 先进润滑与防护材料研究发展中心 |
| 2013 | |
| Source Publication | Journal of Physical Chemistry C
 |
| ISSN | 1932-7447 |
| Volume | 117Issue:20Pages:10375-10382 |
| Abstract | Casein phosphopeptides (CPPs) with abundant phosphoserine clusters can mediate hydroxyapatite (HA) nucleation and growth. In this work, a new type of CPPsbiofuctionalized graphene composite was synthesized by amidation reaction between CPPs and carboxyalated grapheme (CGO). When immersed in stimulated body fluid (1.5 × SBF) at 37 °C for different periods, the CPPs layer on the composite facilitated efficient interaction between the CGO surface and mineral ions, which promoted HA nanoparticle formation and shortened mineralization time in comparison with pristine CGO. The synthesis of the composite mimicked the natural biomineralization of bone, demonstrating that CPPs can effectively improve the bioactivity of graphene and be useful for HA formation. The presented biocomposite may have potential biomedical applications in different areas. |
| Subject Area | 材料科学与物理化学 |
| DOI | 10.1021/jp312163m |
| Funding Organization | the National Natural Science Foundation of China (grant nos. 51075384;51205385);“Top Hundred Talents Program” of Chinese Academy of Sciences |
| Indexed By | SCI |
| If | 4.835 |
| Language | 英语 |
| Funding Project | 聚合物摩擦学组;复合润滑材料组 |
| compositor | 第一作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/4345 |
| Collection | 固体润滑国家重点实验室（LSL） 中国科学院材料磨损与防护重点实验室/先进润滑与防护材料研究发展中心 |
| Corresponding Author | Wang JQ(王金清); Yang SR(杨生荣) |
| Affiliation | 1.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Solid Lubricat, Lanzhou 730000, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100080, Peoples R China 3.Lanzhou Command PLA, Lanzhou Gen Hosp, Dept Stomatol, Lanzhou 730050, Peoples R China |
| Recommended Citation GB/T 7714 | Fan ZJ,Wang JQ,Wang ZF,et al. Casein Phosphopeptide-Biofunctionalized Graphene Biocomposite for Hydroxyapatite Biomimetic Mineralization[J]. Journal of Physical Chemistry C,2013,117(20):10375-10382. |
| APA | Fan ZJ.,Wang JQ.,Wang ZF.,Li ZP.,Qiu YN.,...&杨生荣.(2013).Casein Phosphopeptide-Biofunctionalized Graphene Biocomposite for Hydroxyapatite Biomimetic Mineralization.Journal of Physical Chemistry C,117(20),10375-10382. |
| MLA | Fan ZJ,et al."Casein Phosphopeptide-Biofunctionalized Graphene Biocomposite for Hydroxyapatite Biomimetic Mineralization".Journal of Physical Chemistry C 117.20(2013):10375-10382. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| 8. Fan ZJ (Journal o（4196KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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