| Thermo-responsive hollow silica microgels with controlled drug release properties | |
| Department | 固体润滑国家重点实验室 |
Liu GQ(刘国强)1,3 ; Zhu CL(朱昌玲)1; Xu J(许俊)1,3; Xin Y(辛燕)2; Yang TT(杨婷婷)2; Li J(李静)1; Shi L(石雷)1; Guo ZG(郭志光)1,2; Liu WM(刘维民)1; Guo ZG(郭志光)
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| 2013 | |
| Source Publication | Colloids and Surfaces B: Biointerfaces
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| ISSN | 0927-7765 |
| Volume | 111Pages:7-14 |
| Abstract | Thermo-responsive hollow silica microgels (THSMGs) consisting of a hollow core, an intermediate silica supporting layer and a smart polymer gel corona were fabricated via organic inorganic hybridization. Hollow silica particles and PNIPAAm microgels were successfully combined by utilizing the cross-linking reaction between 3-(trimethoxysilyl) propyl methacrylate (TMSPMA) and silanol groups on the silica surface, and then the copolymerization of TMSPMA and N-isopropylacrylamide (NIPAAm). The morphology and chemical composition were systematically examined by field emission scanning electron microscope (FESEM), transmission electron microscope (TEM), energy dispersive X-ray spectroscopy (EDS) and the Brunauer-Emmett-Teller (BET) measurement. The thermo-responsive phase transition behavior was investigated by the determination of the lower critical solution temperature (LCST), and particle size measurement using dynamic light scattering. THSMGs remain porous even after the coverage of PNIPAAm gels, and also have obvious hydrophilic/hydrophobic transition property and good swelling/collapse capability in spite of the rigid silica layer. The results of in vitro cytotoxicity evaluation and Rhodamine B (RHB) release study demonstrated that THSMGs have good biocompatibility, and achieve a thermo-responsive controlled-release behavior. The prepared THSMGs show considerable potential for applications as targeted and ambient temperature responsive drug delivery system. |
| Keyword | Hollow Silica Microgel Thermo-responsive Porous Structure Controlled Drug Release Rhodamine b |
| Subject Area | 材料科学与物理化学 |
| DOI | 10.1016/j.colsurfb.2013.05.027 |
| Funding Organization | the National Nature Science Foundation of China (No. 50902047;51003025;31070155;11172301);the “Western Light Talent Culture” Project;the “Top Hundred Talents” Program of Chinese Academy of Sciences |
| Indexed By | SCI |
| If | 4.287 |
| Language | 英语 |
| Funding Project | 空间润滑材料组 |
| compositor | 第一作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/4264 |
| Collection | 固体润滑国家重点实验室（LSL） |
| Corresponding Author | Guo ZG(郭志光) |
| Affiliation | 1.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Solid Lubricat, Lanzhou 730000, Peoples R China 2.Hubei Univ, Minist Educ, Key Lab Green Preparat & Applicat Funct Mat, Wuhan 430062, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Liu GQ,Zhu CL,Xu J,et al. Thermo-responsive hollow silica microgels with controlled drug release properties[J]. Colloids and Surfaces B: Biointerfaces,2013,111:7-14. |
| APA | Liu GQ.,Zhu CL.,Xu J.,Xin Y.,Yang TT.,...&郭志光.(2013).Thermo-responsive hollow silica microgels with controlled drug release properties.Colloids and Surfaces B: Biointerfaces,111,7-14. |
| MLA | Liu GQ,et al."Thermo-responsive hollow silica microgels with controlled drug release properties".Colloids and Surfaces B: Biointerfaces 111(2013):7-14. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| Colloids and Surface（2715KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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