| L-Arginine and zinc ion effect on recognition and hydrolysis rate of adenosine 5 '-triphosphate | |
| Department | OSSO国家重点实验室 |
Zhou JY(周巾英)1,2; Lu GX(吕功煊)1 ; Lv GX(吕功煊)
| |
| The second department | erc国家工程研究中心 |
| 2012 | |
| Source Publication | Journal of Coordination Chemistry
 |
| ISSN | 0095-8972 |
| Volume | 65Issue:20Pages:3580-3591 |
| Abstract | Zn2+ can interact with adenosine 5′-triphosphate (ATP) by electrostatic and coordination interactions, and the interaction sites between Zn2+ and ATP vary at different pH in the ATP–Zn2+ binary system. Non-covalent interactions exist between the carboxyl of arginine (Arg) and Zn2+, which led to competition between ATP and Arg to interact with Zn2+ in the ATP–Zn2+–Arg ternary system. Kinetics studies show that the hydrolysis rate constant of ATP in the ATP–Zn2+ binary system was 2.44 × 10−2 min−1, about 11-fold faster than that (2.27 × 10−3 min−1) in the ATP–Zn2+–Arg ternary system. This may be attributed to coordination interactions between the carboxyl of Arg and Zn2+ and the decreased activity of zinc ion toward the phosphate groups via nucleophilic attack. A mechanism that the hydrolysis occurred through an addition–elimination mechanism is proposed. |
| Keyword | Atp Zinc Ion L-arginine Recognition Catalytic Hydrolysis |
| Subject Area | 物理化学与绿色催化 |
| DOI | 10.1080/00958972.2012.713943 |
| Funding Organization | the 973 Program under Grant No. 2009CB22003 |
| Indexed By | SCI |
| If | 1.801 |
| Language | 英语 |
| Funding Project | 环境催化与清洁能源研究组;环境催化与氢能源研究组 |
| compositor | 第一作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/3901 |
| Collection | 羰基合成与选择氧化国家重点实验室（OSSO） 精细石油化工中间体国家工程研究中心（ERC） |
| Corresponding Author | Lv GX(吕功煊) |
| Affiliation | 1.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Gansu, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Zhou JY,Lu GX,Lv GX. L-Arginine and zinc ion effect on recognition and hydrolysis rate of adenosine 5 '-triphosphate[J]. Journal of Coordination Chemistry,2012,65(20):3580-3591. |
| APA | Zhou JY,Lu GX,&吕功煊.(2012).L-Arginine and zinc ion effect on recognition and hydrolysis rate of adenosine 5 '-triphosphate.Journal of Coordination Chemistry,65(20),3580-3591. |
| MLA | Zhou JY,et al."L-Arginine and zinc ion effect on recognition and hydrolysis rate of adenosine 5 '-triphosphate".Journal of Coordination Chemistry 65.20(2012):3580-3591. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| B58.Journal of Coord（515KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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