| Design and synthesis of new chiral pyridine-phosphite ligands for the copper-catalyzed enantioselective conjugate addition of diethylzinc to acyclic enones | |
| Department | OSSO国家重点实验室 |
Xie YJ(谢银君); Huang HM(黄汉民) ; Mo WM(莫为民); Fan XQ(范向群); Shen ZQ(沈志强); Shen ZL(沈振路); Sun N(孙楠); Hu BX(胡宝祥); Hu XQ(胡信全); Hu XQ(胡信全); Huang HM(黄汉民)
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| 2009 | |
| Source Publication | Tetrahedron:Asymmetry
 |
| ISSN | 0957-4166 |
| Volume | 20Pages:1425-1432 |
| Abstract | A series of new chiral pyridine–phosphite ligands have been prepared from (R)-pyridyl alcohols and BINOL-derived chlorophosphite, and successfully employed in the copper-catalyzed enantioselective conjugate addition of diethylzinc to acyclic enones. Using the simple and inexpensive CuBr2 as a precursor, the enantioselective additions to various substituted acyclic enones afforded products in high yields and good enantioselectivities (up to 92% ee). |
| Subject Area | 清洁催化与生物转化 |
| Funding Organization | the National Natural Science Foundation of China (NSFC, 20876149);the Natural Science Foundation of Zhejiang Province (Y406419) |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | 清洁催化与生物转化研究组 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/3654 |
| Collection | 羰基合成与选择氧化国家重点实验室（OSSO） |
| Corresponding Author | Hu XQ(胡信全); Huang HM(黄汉民) |
| Recommended Citation GB/T 7714 | Xie YJ,Huang HM,Mo WM,et al. Design and synthesis of new chiral pyridine-phosphite ligands for the copper-catalyzed enantioselective conjugate addition of diethylzinc to acyclic enones[J]. Tetrahedron:Asymmetry,2009,20:1425-1432. |
| APA | Xie YJ.,Huang HM.,Mo WM.,Fan XQ.,Shen ZQ.,...&黄汉民.(2009).Design and synthesis of new chiral pyridine-phosphite ligands for the copper-catalyzed enantioselective conjugate addition of diethylzinc to acyclic enones.Tetrahedron:Asymmetry,20,1425-1432. |
| MLA | Xie YJ,et al."Design and synthesis of new chiral pyridine-phosphite ligands for the copper-catalyzed enantioselective conjugate addition of diethylzinc to acyclic enones".Tetrahedron:Asymmetry 20(2009):1425-1432. |
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| B5_Tetrahedron Asymm（568KB） | 开放获取 | CC BY-NC-SA | View Application Full Text | |||
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