Four new compounds with cytotoxic and neuroprotective activity from Notopterygium incisum | |
Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Li-Mei Ma1,2; Tian Chai1; Cheng-Bo Wang1; Yi-Dan Zheng3; Li Ma1,2; Xian-Hua Meng1; Kai Wang1,2; Wei-Feng Wang1; Mahdi Moridi Farimani4; Chun-Yan Sang1; Jun-Li Yang1 | |
The second department | 药物化学与新药分子研究团队 |
2022 | |
Source Publication | Phytochemistry Letters |
Issue | 49Pages:138-144 |
Abstract | Phytochemical research on an extract of Notopterygium incisum yielded twenty-four compounds (1–24), including four new compounds 7, 10, 13 and 17. The structures of new compounds were elucidated by spectroscopic analysis, and the absolute configuration of 5 were assigned via Mosher’s method. In addition, compounds 2, 9, 19 and 24 were analyzed by single crystal X-ray analysis for the first time. The new compound 7 exhibited remarkable cytotoxic activity against the human pancreatic cancer cell lines PANC-1, CAPAN-2, CFPAC-1, and SW1990 with IC50 values of 6.25 ± 0.54, 7.74 ± 1.12, 6.68 ± 1.11, and 5.35 ± 0.33 μM, respectively. The primary mechanistic study indicated that 7 caused cell death probably due to induced defects in the mitotic process. Moreover, compounds 2 and 7-9 effectively protected against H2O2-induced neurotoxicity in the SHSY5Y cells, and 1, 3, 6, 10, 11, 16 and 19 exhibited strong DPPH scavenging ability. |
Keyword | Notopterygium incisum Umbelliferae Chemical constituents Cytotoxicity Neuroprotective effect |
DOI | 10.1016/j.phytol.2022.03.007 |
If | 1.873 |
Language | 英语 |
compositor | 第一作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/29295 |
Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Corresponding Author | Chun-Yan Sang; Jun-Li Yang |
Affiliation | 1.CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS) 2.University of Chinese Academy of Sciences 3.College of Life Science, Northwest Normal University 4.Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University |
Recommended Citation GB/T 7714 | Li-Mei Ma,Tian Chai,Cheng-Bo Wang,et al. Four new compounds with cytotoxic and neuroprotective activity from Notopterygium incisum[J]. Phytochemistry Letters,2022(49):138-144. |
APA | Li-Mei Ma.,Tian Chai.,Cheng-Bo Wang.,Yi-Dan Zheng.,Li Ma.,...&Jun-Li Yang.(2022).Four new compounds with cytotoxic and neuroprotective activity from Notopterygium incisum.Phytochemistry Letters(49),138-144. |
MLA | Li-Mei Ma,et al."Four new compounds with cytotoxic and neuroprotective activity from Notopterygium incisum".Phytochemistry Letters .49(2022):138-144. |
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