| A Carabrane-type Sesquiterpenolide Carabrone from Carpesium cernuum Inhibits SW1990 Pancreatic Cancer Cells by Inducing Ferroptosis | |
| Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Yi-Dan Zheng1; Ying Zhang2,3; Jun-Yi Ma1; Chun-Yan Sang2; Jun-Li Yang2
| |
| The second department | 药物化学与新药分子研究团队 |
| 2022 | |
| Source Publication | Molecules
 |
| Issue | 27Pages:5841 |
| Abstract | Pancreatic cancer has an extremely poor prognosis, and the clinical drugs for the treatment of pancreatic cancer are usually multi-drug combinations. Therefore, it is necessary to search for and find specific new bioactive agents against pancreatic cancer. Carabrone is a carabrane-type sesquiterpenolide extracted from Carpesium cernuum L., and this natural compound has been reported to be a potential anti-tumor agent. However, there are few reports on the function of carabrone related to anti-tumor activity in pancreatic cancer. Herein, cell experiments indicated that carabrone had anti-proliferation inhibition and anti-migration and anti-invasion activity against SW1990 cells. Furthermore, the tandem mass spectrometry and network pharmacology analysis showed that this activity may be related to the ferroptosis and Hippo signaling pathway. Taken together, our results demonstrated that carabrone exhibited prominent anti-pancreatic cancer activity and could be a promising agent against pancreatic cancer. |
| Keyword | natural product Carpesium cernuum L. SW1990 cells proteomics ferroptosis |
| DOI | 10.3390/molecules27185841 |
| Indexed By | SCIE |
| If | 4.927 |
| compositor | 第二作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/29274 |
| Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Corresponding Author | Jun-Yi Ma; Chun-Yan Sang; Jun-Li Yang |
| Affiliation | 1.College of Life Science, Northwest Normal University 2.Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences 3.University of Chinese Academy of Sciences |
| Recommended Citation GB/T 7714 | Yi-Dan Zheng,Ying Zhang,Jun-Yi Ma,et al. A Carabrane-type Sesquiterpenolide Carabrone from Carpesium cernuum Inhibits SW1990 Pancreatic Cancer Cells by Inducing Ferroptosis[J]. Molecules,2022(27):5841. |
| APA | Yi-Dan Zheng,Ying Zhang,Jun-Yi Ma,Chun-Yan Sang,&Jun-Li Yang.(2022).A Carabrane-type Sesquiterpenolide Carabrone from Carpesium cernuum Inhibits SW1990 Pancreatic Cancer Cells by Inducing Ferroptosis.Molecules(27),5841. |
| MLA | Yi-Dan Zheng,et al."A Carabrane-type Sesquiterpenolide Carabrone from Carpesium cernuum Inhibits SW1990 Pancreatic Cancer Cells by Inducing Ferroptosis".Molecules .27(2022):5841. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| 2022 Molecules-A Car（5398KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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