LICP OpenIR  > 羰基合成与选择氧化国家重点实验室(OSSO)
Iridium-Catalyzed Enantioselective Unbiased Methylene C(sp(3))-H Borylation of Acyclic Amides
Department羰基合成与选择氧化国家重点实验室(OSSO)
Yang, Yuhuan1,2; Chen, Lili1; Xu, Senmiao1,3
The second department徐森苗课题组
2021-02-08
Source PublicationANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume60Issue:7Pages:3313-3819
Abstract

We herein report amide directed enantioselective beta-C(sp(3))-H borylation of unbiased methylene C-H bonds of acyclic amides enabled by iridium catalysis for the first time. The key to the success of this transformation relies on the careful selection of the combination of iridium precursor and chiral bidentate boryl ligands. A variety of functional groups are well-tolerated, affording chiral beta-functionalized amides in good to excellent enantioselectivities. We also demonstrate the application of the current method by stereospecific conversion of C-B bond into other functionalities.

DOI10.1002/anie.202013568
Funding OrganizationNational Natural Science Foundation of China ; Natural Science Foundation of Jiangsu Province ; Hangzhou Normal University ; Lanzhou Institute of Chemical Physics
Indexed BySCI
If16.823
Language英语
Funding ProjectNational Natural Science Foundation of China[21873261] ; National Natural Science Foundation of China[91956116] ; Natural Science Foundation of Jiangsu Province[BK20170422] ; Hangzhou Normal University ; Lanzhou Institute of Chemical Physics
compositor第一作者单位
WOS Research AreaChemistry
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Cited Times:44[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.licp.cn/handle/362003/28234
Collection羰基合成与选择氧化国家重点实验室(OSSO)
Corresponding AuthorXu, Senmiao
Affiliation1.中国科学院兰州化学物理研究所
2.中国科学院大学
3.杭州师范大学
Corresponding Author AffilicationLanzhou Institute of Chemical Physics,Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Yang, Yuhuan,Chen, Lili,Xu, Senmiao. Iridium-Catalyzed Enantioselective Unbiased Methylene C(sp(3))-H Borylation of Acyclic Amides[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2021,60(7):3313-3819.
APA Yang, Yuhuan,Chen, Lili,&Xu, Senmiao.(2021).Iridium-Catalyzed Enantioselective Unbiased Methylene C(sp(3))-H Borylation of Acyclic Amides.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,60(7),3313-3819.
MLA Yang, Yuhuan,et al."Iridium-Catalyzed Enantioselective Unbiased Methylene C(sp(3))-H Borylation of Acyclic Amides".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 60.7(2021):3313-3819.
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