Iridium-Catalyzed Enantioselective Unbiased Methylene C(sp(3))-H Borylation of Acyclic Amides | |
Department | 羰基合成与选择氧化国家重点实验室(OSSO) |
Yang, Yuhuan1,2; Chen, Lili1; Xu, Senmiao1,3 | |
The second department | 徐森苗课题组 |
2021-02-08 | |
Source Publication | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION |
Volume | 60Issue:7Pages:3313-3819 |
Abstract | We herein report amide directed enantioselective beta-C(sp(3))-H borylation of unbiased methylene C-H bonds of acyclic amides enabled by iridium catalysis for the first time. The key to the success of this transformation relies on the careful selection of the combination of iridium precursor and chiral bidentate boryl ligands. A variety of functional groups are well-tolerated, affording chiral beta-functionalized amides in good to excellent enantioselectivities. We also demonstrate the application of the current method by stereospecific conversion of C-B bond into other functionalities. |
DOI | 10.1002/anie.202013568 |
Funding Organization | National Natural Science Foundation of China ; Natural Science Foundation of Jiangsu Province ; Hangzhou Normal University ; Lanzhou Institute of Chemical Physics |
Indexed By | SCI |
If | 16.823 |
Language | 英语 |
Funding Project | National Natural Science Foundation of China[21873261] ; National Natural Science Foundation of China[91956116] ; Natural Science Foundation of Jiangsu Province[BK20170422] ; Hangzhou Normal University ; Lanzhou Institute of Chemical Physics |
compositor | 第一作者单位 |
WOS Research Area | Chemistry |
Publisher | WILEY-V C H VERLAG GMBH |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/28234 |
Collection | 羰基合成与选择氧化国家重点实验室(OSSO) |
Corresponding Author | Xu, Senmiao |
Affiliation | 1.中国科学院兰州化学物理研究所 2.中国科学院大学 3.杭州师范大学 |
Corresponding Author Affilication | Lanzhou Institute of Chemical Physics,Chinese Academy of Sciences |
Recommended Citation GB/T 7714 | Yang, Yuhuan,Chen, Lili,Xu, Senmiao. Iridium-Catalyzed Enantioselective Unbiased Methylene C(sp(3))-H Borylation of Acyclic Amides[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2021,60(7):3313-3819. |
APA | Yang, Yuhuan,Chen, Lili,&Xu, Senmiao.(2021).Iridium-Catalyzed Enantioselective Unbiased Methylene C(sp(3))-H Borylation of Acyclic Amides.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,60(7),3313-3819. |
MLA | Yang, Yuhuan,et al."Iridium-Catalyzed Enantioselective Unbiased Methylene C(sp(3))-H Borylation of Acyclic Amides".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 60.7(2021):3313-3819. |
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Angew Chem Int Ed - (1638KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text |
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