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Synthesis of charged chitosan nanoparticles as functional biolubricant
Department固体润滑国家重点实验室(LSL)
Lumin Yang; Xiaoduo Zhao; Jing Zhang; Shuanhong Ma; Lei Jiang; Qiangbing Wei; Meirong Cai; Feng Zhou
The second department材料表面界面组
2021-07-15
Source PublicationColloids and Surfaces B: Biointerfaces
Volume206Issue:***Pages:***
Abstract

Osteoarthritis has been a major disease in recent years, which is mainly related to the breakdown of the lubrication function of the cartilage sliding interface, along with the inflammation of the joint capsule. In this paper, one kind of novel biomimetic nanoparticles (NPs) lubricant, named CS-PS, is synthesized through chemically grafting hydrophilic sulfonic acid (SO3 − ) groups onto the surface of biocompatible and biodegradable chitosan (CS) NPs. Compared with control CS NPs, the as-synthesized CS-PS NPs exhibits excellent hydration and stability because of negatively charged surface zeta potential, along with extraordinary lubrication performance in water for realizing a super-low friction coefficient (COF) as ~0.01 at the sliding interface of PDMS elastomer-Ti6Al4V disk. Correspondingly, the CS-PS NPs can also be used as a drug carrier for aspirin, which presents very good drug loading and release behavior in PBS (pH = 7.4). MCS cells culture experiment proves that this kind of novel lubricant is nontoxic and biocompatible, for which may be expected to use as potential articular injective material for the treatment of osteoarthritis.

Keywordsurface modification drug release nanoparticles osteoarthritis water lubrication
MOST Discipline Catalogue工学
DOI10.1016/j.colsurfb.2021.111973
URL查看原文
Indexed BySCI
If5.3
Language英语
compositor第一作者单位
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.licp.cn/handle/362003/27793
Collection固体润滑国家重点实验室(LSL)
Corresponding AuthorShuanhong Ma; Feng Zhou
Affiliation1.兰州化学物理研究所,固体润滑国家重点实验室
2.兰州化学物理研究所,固体润滑国家重点实验室
3.西北高原生物研究所,藏药研究重点实验室,青海省藏药研究重点实验室
4.兰州化学物理研究所,固体润滑国家重点实验室
5.西北高原生物研究所,藏药研究重点实验室,青海省藏药研究重点实验室
6.西北师范大学化学化工学院,生态环境相关高分子材料教育部重点实验室,甘肃省高分子材料重点实验室
7.兰州化学物理研究所,固体润滑国家重点实验室
8.兰州化学物理研究所,固体润滑国家重点实验室
Recommended Citation
GB/T 7714
Lumin Yang,Xiaoduo Zhao,Jing Zhang,et al. Synthesis of charged chitosan nanoparticles as functional biolubricant[J]. Colloids and Surfaces B: Biointerfaces,2021,206(***):***.
APA Lumin Yang.,Xiaoduo Zhao.,Jing Zhang.,Shuanhong Ma.,Lei Jiang.,...&Feng Zhou.(2021).Synthesis of charged chitosan nanoparticles as functional biolubricant.Colloids and Surfaces B: Biointerfaces,206(***),***.
MLA Lumin Yang,et al."Synthesis of charged chitosan nanoparticles as functional biolubricant".Colloids and Surfaces B: Biointerfaces 206.***(2021):***.
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