Palladium-Catalyzed Tandem Carbonylative Aza-Wacker-Type Cyclization of Nucleophile Tethered Alkene to Access Fused N-Heterocycles | |
Department | 羰基合成与选择氧化国家重点实验室(OSSO) |
Shi Lijun1,2; Wen Mingshan1; Li Fuwei1 | |
The second department | 清洁催化与合成 |
2021-09-27 | |
Source Publication | Chinese Journal of Chemistry |
Volume | 39Issue:2Pages:317-322 |
Abstract | Although tandem reactions offer rapid access to structurally complex molecules in one-pot reaction, the selectivity issue needs to be addressed particularly when incompatible step reactions are involved. Herein, we report the selective synthesis of fused N-heterocycles from nucleophile-tethered alkenylamide and carbon monoxide via palladium (Pd)-catalyzed tandem carbonylative aza-Wacker-type cyclization. The electron-deficient nature of amide N—H and the intramolecular coordination of Pd with alkene accelerate the aminopalladation and effectively prevent the side oxidative carbonylation of diamine moiety to form urea. It is also found that the reported acyl Pd chloride intermediate may not be involved in this tandem cyclization. This work not only provides an efficient synthetic route to fused 1,4-diazepanones and 1,4-diazepanes but also inspires further development of tandem reactions for the diverse synthesis of heterocycles. |
Keyword | Palladium Tandem reaction Carbonylation Heterocycles Alkenes |
DOI | 10.1002/cjoc.202000491 |
If | 6.0 |
Language | 英语 |
compositor | 第一作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/27686 |
Collection | 羰基合成与选择氧化国家重点实验室(OSSO) 苏州研究院 |
Corresponding Author | Li Fuwei |
Affiliation | 1.State Key Laboratory for Oxo Synthesis and Selective Oxidation, Suzhou Research Institute of LICP, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, Gansu 730000, China 2.University of the Chinese Academy of Sciences, Beijing 100049, China |
Recommended Citation GB/T 7714 | Shi Lijun,Wen Mingshan,Li Fuwei. Palladium-Catalyzed Tandem Carbonylative Aza-Wacker-Type Cyclization of Nucleophile Tethered Alkene to Access Fused N-Heterocycles[J]. Chinese Journal of Chemistry,2021,39(2):317-322. |
APA | Shi Lijun,Wen Mingshan,&Li Fuwei.(2021).Palladium-Catalyzed Tandem Carbonylative Aza-Wacker-Type Cyclization of Nucleophile Tethered Alkene to Access Fused N-Heterocycles.Chinese Journal of Chemistry,39(2),317-322. |
MLA | Shi Lijun,et al."Palladium-Catalyzed Tandem Carbonylative Aza-Wacker-Type Cyclization of Nucleophile Tethered Alkene to Access Fused N-Heterocycles".Chinese Journal of Chemistry 39.2(2021):317-322. |
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