Neuroprotective Effects of Triterpenoids from Camellia japonica against Amyloid β-Induced Neuronal Damage | |
Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Hyo-Moon Cho1; Thi-Kim-Quy Ha1,2; Thi-Phuong Doan1; Basanta Dhodary1; Jin-Pyo An1; Ba-Wool Lee1; Yang JL(杨军丽)3; Won-Keun Oh1 | |
The second department | 505t组 |
2020 | |
Source Publication | Journal of Natural Products |
Volume | 83Issue:7Pages:2076–2086 |
Abstract | Alzheimer’s disease (AD), a neurocognitive impairment affecting human mental capacity, is related to the accumulation of amyloid-β peptide (Aβ) and the hyperphosphorylation of tau protein. In addition to modern therapies approved for AD treatment, natural products with antioxidant and anti-inflammatory properties have been studied for their potential to prevent AD pathogenesis. Six new noroleanane triterpenoids from the fruit peels of Camellia japonica were isolated, and their structures were determined by diverse spectroscopic methods. The neuroprotective effects of the six new compounds were tested against Aβ-induced neurotoxicity and neuroinflammation in mouse hippocampal and microglial cells. In the model of HT22-transfected cells, compounds 1–4 showed strongly neuroprotective effects via antioxidant response element gene activation and decreased the level of glutamate uptake. Compounds 1–4 also appeared to have strong inhibitory effects on NO production in Aβ1–42-transfected BV2 microglial cells. A docking simulation study was used to explain the inhibitory effects of compounds 1–4 on β-secretase 1 (BACE1). Noroleanane triterpenoids 1–4 had potential neuroprotective and anti-inflammatory effects against Aβ-induced neuronal damage. The structure–activity relationships of the 30 oleanane triterpenoids from C. japonica were assessed in a model of Aβ1–42-transfected HT22 cells. |
MOST Discipline Catalogue | 理学::化学 |
DOI | doi.org/10.1021/acs.jnatprod.9b00964 |
Indexed By | SCI |
If | 3.779 |
Language | 英语 |
compositor | 第三作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/26520 |
Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Corresponding Author | Won-Keun Oh |
Affiliation | 1.Seoul National University 2.Cantho University 3.Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences |
Recommended Citation GB/T 7714 | Hyo-Moon Cho,Thi-Kim-Quy Ha,Thi-Phuong Doan,et al. Neuroprotective Effects of Triterpenoids from Camellia japonica against Amyloid β-Induced Neuronal Damage[J]. Journal of Natural Products,2020,83(7):2076–2086. |
APA | Hyo-Moon Cho.,Thi-Kim-Quy Ha.,Thi-Phuong Doan.,Basanta Dhodary.,Jin-Pyo An.,...&Won-Keun Oh.(2020).Neuroprotective Effects of Triterpenoids from Camellia japonica against Amyloid β-Induced Neuronal Damage.Journal of Natural Products,83(7),2076–2086. |
MLA | Hyo-Moon Cho,et al."Neuroprotective Effects of Triterpenoids from Camellia japonica against Amyloid β-Induced Neuronal Damage".Journal of Natural Products 83.7(2020):2076–2086. |
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JNP_Neuroprotective (3261KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text |
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