Dammarane-Type Saponins from Gynostemma pentaphyllum Prevent Hypoxia-Induced Neural Injury through Activation of ERK, Akt, and CREB Pathways

doi:doi.org/10.1021/acs.jafc.9b06659

LICP OpenIR > 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室

	Dammarane-Type Saponins from Gynostemma pentaphyllum Prevent Hypoxia-Induced Neural Injury through Activation of ERK, Akt, and CREB Pathways
Department	中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室
	Wang J(王君)1,5; Zhao M(赵名)2; Xiang Cheng 2; Ying Han 2; Tong Zhao 2; Ming Fan 2,3,4; Zhu LL(朱玲玲)2,3; Yang JL(杨军丽)1
The second department	505t组
	2020
Source Publication	Journal of Agricultural and Food Chemistry
Volume	68 Issue:1 Pages:193−205
Abstract	Gynostemma pentaphyllum possesses neuroprotective bioactivity. However, the effect of gypenosides on hypoxia-induced neural damage remains obscure. In this study, Gyp, the active fraction extracted from G. pentaphyllum and its bioactive compounds as well as the underlying molecular mechanisms were investigated. Eighteen dammarane-type saponins were isolated from Gyp. The absolute configurations of six unreported compounds (13–18) were assessed via electron capture detection (ECD) analyses. The results of cell viability assay showed that Gyp and its bioactive compounds (13–16 and 18) effectively protected PC12 cells from hypoxia injury. Gyp pretreatment also improved mice spatial memory impairment caused by hypoxia exposure. At the molecular level, Gyp and its bioactive compounds could activate the signaling pathways of ERK, Akt, and CREB in vitro and in vivo. In summary, Gyp and its bioactive compounds could prevent hypoxia-induced injury via ERK, Akt, and CREB signaling pathways.
Keyword	Gynostemma pentaphyllum dammarane-type saponins hypoxia-induced neural injury
MOST Discipline Catalogue	理学::化学
DOI	doi.org/10.1021/acs.jafc.9b06659
Indexed By	SCI
If	4.192
Language	英语
compositor	第一作者单位
Citation statistics
Document Type	期刊论文
Identifier	http://ir.licp.cn/handle/362003/26518
Collection	中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室
Corresponding Author	Zhu LL(朱玲玲); Yang JL(杨军丽)
Affiliation	1.Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS) 2.Academy of Military Medical Sciences 3.Nantong University 4.Capital Medical University 5.University of Chinese Academy of Sciences
Recommended Citation GB/T 7714	Wang J,Zhao M,Xiang Cheng,et al. Dammarane-Type Saponins from Gynostemma pentaphyllum Prevent Hypoxia-Induced Neural Injury through Activation of ERK, Akt, and CREB Pathways[J]. Journal of Agricultural and Food Chemistry,2020,68(1):193−205.
APA	Wang J.,Zhao M.,Xiang Cheng.,Ying Han.,Tong Zhao.,...&Yang JL.(2020).Dammarane-Type Saponins from Gynostemma pentaphyllum Prevent Hypoxia-Induced Neural Injury through Activation of ERK, Akt, and CREB Pathways.Journal of Agricultural and Food Chemistry,68(1),193−205.
MLA	Wang J,et al."Dammarane-Type Saponins from Gynostemma pentaphyllum Prevent Hypoxia-Induced Neural Injury through Activation of ERK, Akt, and CREB Pathways".Journal of Agricultural and Food Chemistry 68.1(2020):193−205.

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