Bungsteroid A: One Unusual C 34 Pentacyclic Steroid Analogue from Zanthoxylum bungeanum Maxim | |
Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Meng XH(孟宪华); Chai T(柴甜); Shi YP(师彦平); Yang JL(杨军丽) | |
The second department | 505t组 |
2020-07 | |
Source Publication | the Journal of Organic Chemistry |
Volume | 85Issue:16Pages:10806−10812 |
Abstract | Bungsteroid A (1), possessing an unreported carbon skeleton, was isolated from the pericarps of Zanthoxylum bungeanum Maxim. It represents the first carbon skeleton of a C34 steroid analogue featuring a unique 6/6/6/6/5-fused pentacyclic skeleton, which has been determined by spectroscopic methods, quantum-chemical 13C NMR, ECD calculations, and calculations of optical rotations. Bungsteroid A showed the antiproliferative effects against HepG2, MCF-7, and HeLa cell lines with the IC50 values of 56.3 ± 1.1, 64.2 ± 0.9, and 74.2 ± 1.3 μM, respectively. |
Keyword | Zanthoxylum bungeanum Maxim quantum-chemical 13C NMR ECD antiproliferative effect steroid |
MOST Discipline Catalogue | 理学::化学 |
DOI | doi.org/10.1021/acs.joc.0c01312 |
Indexed By | SCI |
If | 4.335 |
Language | 英语 |
compositor | 第一作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/26510 |
Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Corresponding Author | Meng XH(孟宪华) |
Affiliation | Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS) |
Recommended Citation GB/T 7714 | Meng XH,Chai T,Shi YP,et al. Bungsteroid A: One Unusual C 34 Pentacyclic Steroid Analogue from Zanthoxylum bungeanum Maxim[J]. the Journal of Organic Chemistry,2020,85(16):10806−10812. |
APA | Meng XH,Chai T,Shi YP,&Yang JL.(2020).Bungsteroid A: One Unusual C 34 Pentacyclic Steroid Analogue from Zanthoxylum bungeanum Maxim.the Journal of Organic Chemistry,85(16),10806−10812. |
MLA | Meng XH,et al."Bungsteroid A: One Unusual C 34 Pentacyclic Steroid Analogue from Zanthoxylum bungeanum Maxim".the Journal of Organic Chemistry 85.16(2020):10806−10812. |
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JOC_Bungsteroid A, O(1511KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text |
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