Polymerization induced phase separation as a generalized methodology for multi-layered hydrogel tubes | |
Department | 固体润滑国家重点实验室 |
Mingming Rong1,2; Shuanhong Ma1; Peng Lin3; Meirong Cai1; Zijian Zheng4; Feng Zhou1 | |
The second department | 材料表界面组 |
2019-04-30 | |
Source Publication | Journal of Materials Chemistry B |
Issue | 7Pages:3505-3511 |
Abstract | Herein, we report a conceptually chemical strategy to facilitate the fabrication of layered hydrogel tubes based on the polymerization-induced phase separation mechanism. In a typical case, a high purity iron wire is immersed into a sodium alginate (SA) saturated 2-hydroxyethyl methacrylate (HEMA) monomer solution to perform Surface Catalytically Initiated Radical Polymerization (SCIRP), followed by Ca2+ post-crosslinking. Subsequently, the successful removal of the iron wire template enables the formation of a hollow PHEMA/SA–Ca2+ layered hydrogel tube. The layered hydrogel tubes can be prepared with tunable sizes, good tensile strength, perfusable 3D complex structure and minimal cytotoxicity. Multi-layered hydrogel tubes can be obtained as well on the basis of monomers diffusion and re-initiation mechanism, which may address the demands for tissue manufacturing. Finally, the bioactivity of the PHEMA/SA–Ca2+ layered hydrogel tube is proved by the surface adhesion and proliferation of two types of cells-NIH3T3 and PAECs on the inner side of the layered hydrogel tubes. |
Keyword | SCIRP layered hydrogel tube |
MOST Discipline Catalogue | 理学::化学 |
DOI | 10.1039/C9TB00185A |
Indexed By | SCI |
If | 5.047 |
compositor | 第一作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/25732 |
Collection | 固体润滑国家重点实验室(LSL) |
Corresponding Author | Shuanhong Ma; Feng Zhou |
Affiliation | 1.中国科学院兰州化学物理研究所 2.中国科学院院大学 3.安徽工业大学 4.香港理工大学 |
Corresponding Author Affilication | Lanzhou Institute of Chemical Physics,Chinese Academy of Sciences |
Recommended Citation GB/T 7714 | Mingming Rong,Shuanhong Ma,Peng Lin,et al. Polymerization induced phase separation as a generalized methodology for multi-layered hydrogel tubes[J]. Journal of Materials Chemistry B,2019(7):3505-3511. |
APA | Mingming Rong,Shuanhong Ma,Peng Lin,Meirong Cai,Zijian Zheng,&Feng Zhou.(2019).Polymerization induced phase separation as a generalized methodology for multi-layered hydrogel tubes.Journal of Materials Chemistry B(7),3505-3511. |
MLA | Mingming Rong,et al."Polymerization induced phase separation as a generalized methodology for multi-layered hydrogel tubes".Journal of Materials Chemistry B .7(2019):3505-3511. |
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c9tb00185a.pdf(4040KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text |
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