Advances in Screening Enzyme Inhibitors by Capillary Electrophoresis | |
Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Wei-Feng Wang; Jun-Li Yang | |
The second department | 505t |
2019-05 | |
Source Publication | Electrophoresis |
Volume | 40Issue:16-17Pages:2075–2083 |
Abstract | Capillary electrophoresis (CE) has attracted lots of attention due to its simplicity, low sample consumption, low solvent volume, high resolution, and high speed. Based on these advantages, it has been widely used in enzyme inhibitor screening. There are two main operation modes on enzyme inhibitor screening: off‐line (precapillary enzyme assays) in which process CE was used as an analytical tool; online (in‐capillary enzyme assays) which combined the sample injection, mix, reaction, separation, and detection within a single run. Additionally, diverse of new materials were introduced to immobilize enzyme, which has been coupled with CE for the study of enzyme activity and its inhibitor screening. This review gives an overview of the developments and applications for the CE‐based enzyme inhibitor screening. |
Keyword | Capillary electrophoresis Enzyme inhibitor Immobilization Screening |
MOST Discipline Catalogue | 理学::化学 |
DOI | DOI 10.1002/elps.201900013 |
Indexed By | SCI |
If | 2.754 |
Language | 英语 |
compositor | 第一作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/25444 |
Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Corresponding Author | Jun-Li Yang |
Affiliation | Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences |
Recommended Citation GB/T 7714 | Wei-Feng Wang,Jun-Li Yang. Advances in Screening Enzyme Inhibitors by Capillary Electrophoresis[J]. Electrophoresis,2019,40(16-17):2075–2083. |
APA | Wei-Feng Wang,&Jun-Li Yang.(2019).Advances in Screening Enzyme Inhibitors by Capillary Electrophoresis.Electrophoresis,40(16-17),2075–2083. |
MLA | Wei-Feng Wang,et al."Advances in Screening Enzyme Inhibitors by Capillary Electrophoresis".Electrophoresis 40.16-17(2019):2075–2083. |
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File Name/Size | DocType | Version | Access | License | ||
Electrophoresis_Adva(620KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text |
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