| Effect of attapulgite contents on release behaviors of a pH sensitive carboxymethyl cellulose-g-poly(acrylic acid)/attapulgite/sodium alginate composite hydrogel bead containing diclofenac | |
| Department | 环境材料与生态化学研究发展中心 |
Wang Q(汪琴)1 ; Wang WB(王文波)1; Wu J(吴洁)2; Wang AQ(王爱勤)1,2; Wang AQ(王爱勤)
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| 2012 | |
| Source Publication | Journal of Applied Polymer Science
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| ISSN | 0021-8995 |
| Volume | 124Issue:6Pages:4424-4432 |
| Abstract | A series of pH-sensitive composite hydrogel beads, carboxymethyl cellulose-g-poly(acrylic acid)/attapulgite/sodium alginate (CMC-g-PAA/APT/SA), were prepared by combining CMC-g-PAA/APT composite and SA, using Ca2+ as the ionic crosslinking agent and diclofenac sodium (DS) as the model drug. The effects of APT content and external pH on the swelling properties and release behaviors of DS from the composite hydrogel beads were investigated. The results showed that the composite hydrogel beads exhibited good pH-sensitivity. Introducing 20% APT into CMC-g-PAA hydrogel could change the surface structure of the composite hydrogel beads, decrease the swelling ability, and relieve the burst release effect of DS. The drug cumulative release ratio of DS from the hydrogel beads in simulated gastric fluid was only 3.71% within 3 hour, but in simulated intestinal fluid about 50% for 3 hour, 85% for 12 hour, up to 90% after 24 hour. The obtained results indicated that the CMC-g-PAA/APT/SA hydrogel beads could be applied to the drug delivery system as drug carriers in the intestinal tract. |
| Keyword | Composite Hydrogel Carboxymethyl Cellulose Attapulgite Ph-sensitive Controlled Release |
| Subject Area | 环境材料与生态化学 |
| DOI | 10.1002/app.35440 |
| Funding Organization | Jiangsu Provincial Science and Technology Office; contract grant number: BE2009098;Special Research Fund of Scholarship of Dean of CAS. |
| Indexed By | SCI |
| If | 1.395 |
| Language | 英语 |
| Funding Project | 功能复合材料组 |
| compositor | 第一作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/2532 |
| Collection | 环境材料与生态化学研究发展中心 |
| Corresponding Author | Wang AQ(王爱勤) |
| Affiliation | 1.Chinese Acad Sci, Lanzhou Inst Chem Phys, Ctr Ecomat & Green Chem, Lanzhou 730000, Peoples R China 2.Huaiyin Inst Technol, Key Lab Attapulgite Sci & Appl Technol Jiangsu Pr, Huaian 223003, Peoples R China |
| Recommended Citation GB/T 7714 | Wang Q,Wang WB,Wu J,et al. Effect of attapulgite contents on release behaviors of a pH sensitive carboxymethyl cellulose-g-poly(acrylic acid)/attapulgite/sodium alginate composite hydrogel bead containing diclofenac[J]. Journal of Applied Polymer Science,2012,124(6):4424-4432. |
| APA | Wang Q,Wang WB,Wu J,Wang AQ,&王爱勤.(2012).Effect of attapulgite contents on release behaviors of a pH sensitive carboxymethyl cellulose-g-poly(acrylic acid)/attapulgite/sodium alginate composite hydrogel bead containing diclofenac.Journal of Applied Polymer Science,124(6),4424-4432. |
| MLA | Wang Q,et al."Effect of attapulgite contents on release behaviors of a pH sensitive carboxymethyl cellulose-g-poly(acrylic acid)/attapulgite/sodium alginate composite hydrogel bead containing diclofenac".Journal of Applied Polymer Science 124.6(2012):4424-4432. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| 2012124644244432.pdf（1653KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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