| Analytical and semipreparative resolution of enatiomers of albendazole sulfoxide by HPLC on amylose tris (3,5-dimethylphenylcarbamate) chiral stationary phases | |
| Department | 甘肃省天然药物重点实验室 |
Zhai ZD(翟宗德); Luo XP(罗兴平); Wu XM(吴小梅); Zhang H(张虹); Shi YP(师彦平) ; Chen LR(陈立仁); Li YM(李永民)
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| 2005 | |
| Source Publication | Journal of Biochemical and Biophysical Methods
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| ISSN | 0165-022X |
| Volume | 62Pages:69-79 |
| Abstract | Broad spectrum anthelmintic agent—albendazole sulfoxide (ABZSO) have been separated and semiprepared on amylose tris (3,5-dimethylphenylcarbamate) chiral stationary phases by HPLC using mobile phases contained with n-hexane and different alcohols. For analytical separation the influence of the nature and content of alcoholic modifiers on separation were systemically studied. Then, the analytical methods were scaled up to semipreparative loading to obtain small quantities (about 1 g) of both ABZSO enantiomers. Especially, different loading amounts were investigated for their effect on various parameters of semipreparative HPLC. In addition, optical rotation and circular dichroism (CD) of both ABZSO enantiomers collected were determined and single enantiomers were found stable in configuration for 1 year. |
| Keyword | Enantioseparation Polysaccharide Carbamate Phase Semipreparative Hplc Optical Rotation Circular Dichroism Albendazole Sulfoxide |
| Subject Area | 分析化学 ; 药物化学 |
| Funding Organization | the ministry of science and technology of China under “Basic Study and Prompt Support Program” (No. [2001] 51);the Chinese Academy of Sciences under a “Hundreds of Talents Program” |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | 抗糖尿病中药古方活性组份的发现及其高效液相色谱-质谱联用仪系统性研究 ; 分子自组装法制备表层金属氧化物/二氧化硅新型HPLC固定相的研究 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/2496 |
| Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Corresponding Author | Zhai ZD(翟宗德) |
| Recommended Citation GB/T 7714 | Zhai ZD,Luo XP,Wu XM,et al. Analytical and semipreparative resolution of enatiomers of albendazole sulfoxide by HPLC on amylose tris (3,5-dimethylphenylcarbamate) chiral stationary phases[J]. Journal of Biochemical and Biophysical Methods,2005,62:69-79. |
| APA | 翟宗德.,罗兴平.,吴小梅.,张虹.,师彦平.,...&李永民.(2005).Analytical and semipreparative resolution of enatiomers of albendazole sulfoxide by HPLC on amylose tris (3,5-dimethylphenylcarbamate) chiral stationary phases.Journal of Biochemical and Biophysical Methods,62,69-79. |
| MLA | 翟宗德,et al."Analytical and semipreparative resolution of enatiomers of albendazole sulfoxide by HPLC on amylose tris (3,5-dimethylphenylcarbamate) chiral stationary phases".Journal of Biochemical and Biophysical Methods 62(2005):69-79. |
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