Nanocellulose 3, 5-Dimethylphenylcarbamate Derivative Coated Chiral Stationary Phase: Preparation and Enantioseparation Performance | |
Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Zhang Xiaoli1,2; Wang Litao1; Dong Shuqing1; Zhang Xia1; Wu Qi1,2; Zhao Liang1; Shi Yanping1 | |
2016 | |
Source Publication | Chirality |
Volume | 28Issue:5Pages:376-381 |
Abstract | Nanocrystalline cellulose (NCC) with high surface area and high ordered crystalline structure was prepared from microcrystalline cellulose (MCC) under the hydrolysis of sodium hypochlorite. NCC was further reacted with 3,5-dimethylphenyl isocyanate to obtain the nanocellulose derivative, and then coated successfully on the surface of silica gel to a prepared NCC-coated chiral stationary phase (CSP) as a new kind of chiral separation material. Similarly, MCC derivative-coated CSP was also prepared as contrast. The chiral separation performance of NCC-based CSP was evaluated and compared with MCC-based CSP by high-performance liquid chromatography. Moreover, the effects of the alcohol modifiers, mobile phase additives, and low rates on chiral separations were investigated in detail. The results showed that 10 chiral compounds were separated on NCC-based CSP with better peak shape and higher column efficiency than MCC-based CSP, which confirmed that NCC-based CSP was a promising packing material for the resolution of chiral compounds. |
Keyword | Nanocrystalline Cellulose 3, 5-dimethylphenylcarbamate Chiral Stationary Phases Enantioseparation High Performance Liquid Chromatography |
MOST Discipline Catalogue | 理学 ; 理学::化学 |
DOI | 10.1002/chir.22578 |
Indexed By | SCI ; SCIE |
If | 1.833 |
Language | 英语 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/24651 |
Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Corresponding Author | Zhao Liang; Shi Yanping |
Affiliation | 1.Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Science, Lanzhou, Gansu Province, P.R. China 2.University of Chinese Academy of Sciences, Beijing, P.R. China |
Recommended Citation GB/T 7714 | Zhang Xiaoli,Wang Litao,Dong Shuqing,et al. Nanocellulose 3, 5-Dimethylphenylcarbamate Derivative Coated Chiral Stationary Phase: Preparation and Enantioseparation Performance[J]. Chirality,2016,28(5):376-381. |
APA | Zhang Xiaoli.,Wang Litao.,Dong Shuqing.,Zhang Xia.,Wu Qi.,...&Shi Yanping.(2016).Nanocellulose 3, 5-Dimethylphenylcarbamate Derivative Coated Chiral Stationary Phase: Preparation and Enantioseparation Performance.Chirality,28(5),376-381. |
MLA | Zhang Xiaoli,et al."Nanocellulose 3, 5-Dimethylphenylcarbamate Derivative Coated Chiral Stationary Phase: Preparation and Enantioseparation Performance".Chirality 28.5(2016):376-381. |
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