KMS Lanzhou Institute of Chemical Physics,Chinese Academy of Sciences
Hypoglycemic Triterpenes from Gynostemma pentaphyllum | |
Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Wang, Jun(王君)1,2; Ha, Thi Kim Quy3; Shi, Yan-Ping(师彦平)1; Oh, Won Keun3; Yang, Jun-Li1 | |
2018 | |
Source Publication | Phytochemistry |
Volume | 155Issue:-Pages:171-181 |
Abstract | To search for bioactive gypenosides and their analogues, a saponin enriched fraction and its hydrolyzate from Gynostemma pentaphyllum were phytochemically investigated. Fractionation by diverse chromatographic methods, including HPLC, Sephadex LH-20, silica gel, and C18 reverse phase silica gel, led to the isolation and purification of twelve triterpenes, including five undescribed and seven known. The chemical structures of all compounds were determined as analyzed by nuclear magnetic resonance (NMR), high resolution mass spectrometry (HR-MS), infrared spectrum (IR), optical rotation, and chemical transformations. Among all isolates,nine compounds possessed a rare dammarane triterpenoid framework with A-ring modified. The relative configurations of three compounds were determined by 2D NMR for the first time. The absolute configurations of four compounds were determined by the modified Mosher's method. Two of all isolated compounds significantly enhanced 2-deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-D-glucose (2-NBDG) uptake and Glucose Transporter 4 (GLUT4) translocation via activating the AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) signaling pathway. This study provided the potential candidates for the development of antidiabetic agents. |
Keyword | Gynostemma Pentaphyllum Cucurbitaceae Triterpenes Insulin Mimetic Activity |
Subject Area | 天然产物有机化学 |
MOST Discipline Catalogue | 理学::化学 |
DOI | 10.1016/j.phytochem.2018.08.008 |
Indexed By | SCI |
If | 3.186 |
Language | 英语 |
compositor | 第一作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/23945 |
Collection | 个人在本单位外知识产出 |
Corresponding Author | Oh, Won Keun; Yang, Jun-Li |
Affiliation | 1.Lanzhou Institute of Chemical Physics (LICP), Chinese Academy of Sciences 2.University of Chinese Academy of Sciences, Chinese Academy of Sciences 3.Seoul National University, Korea |
Recommended Citation GB/T 7714 | Wang, Jun,Ha, Thi Kim Quy,Shi, Yan-Ping,et al. Hypoglycemic Triterpenes from Gynostemma pentaphyllum[J]. Phytochemistry,2018,155(-):171-181. |
APA | Wang, Jun,Ha, Thi Kim Quy,Shi, Yan-Ping,Oh, Won Keun,&Yang, Jun-Li.(2018).Hypoglycemic Triterpenes from Gynostemma pentaphyllum.Phytochemistry,155(-),171-181. |
MLA | Wang, Jun,et al."Hypoglycemic Triterpenes from Gynostemma pentaphyllum".Phytochemistry 155.-(2018):171-181. |
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Phytochemistry_Hypog(1090KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text |
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