A review on chiral separation by counter-current chromatography: Development, applications and future outlook | |
Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Huang XY(黄新异)1; Pei D(裴栋)1,2; Liu JF(刘建飞)1; Di DL(邸多隆)1,2 | |
The second department | 青岛研发中心/青岛市资源化学与新材料研究中心 |
2018 | |
Source Publication | Journal of Chromatography A |
ISSN | 0021-9673 |
Volume | 1531Issue:0Pages:1-12 |
Abstract | Chiral separation has been a remarkably active area of research over the past long time and it still stays that way. Over the last few decades, counter-current chromatography (CCC) was successfully applied to the field of chiral separation. It provides an attractive approach to obtain pure enantiomer, particularly in preparative application because of its unique advantages of high load capacity, low solvent consumption and easy scale-up. The last several years great strides have been made in chiral separation by CCC, ranging from novel elution modes such as recycling elution mode and multiple dual mode elution to more specialized approaches such as pH-zone-refining and biphasic chiral recognition technologies. These developments have greatly improved the resolution of enantiomers and promoted the application of CCC in the field of chiral separation. Although not as popular as its application to the field of separation of natural product, the development of chiral separation by CCC should not be underrated. In this review article, we refer to the development, applications and future outlook of chiral separation by CCC, with emphasis on topics of its history, mechanism, advantages, limitations, current development and challenges. Meanwhile, its orientation of continued evolution and future outlook also have been discussed. While some scientific and technological problems have not yet been solved thoroughly, chiral separation by CCC has demonstrated potential advantages and prospects in this field and has good chance at preparative enantioseparation. |
Keyword | Chiral Separation High-speed Counter Current Chromatography Centrifugal Partition Chromatography |
Subject Area | 分析化学与药物化学 |
DOI | 10.1016/j.chroma.2017.10.073 |
Funding Organization | the National Natural Sciences Foundation of China (NSFC No. 21505144 ; 21605149) ; the Natural Science Foundation of GansuProvince (No. 1506RJZA283) ; Youth Innovation PromotionAssociation CAS (No. 2016369) |
Indexed By | SCI |
If | 3.716 |
Language | 英语 |
Funding Project | 药物工艺标准研究组 |
compositor | 第一作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/23751 |
Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 青岛研发中心/青岛市资源化学与新材料研究中心 |
Corresponding Author | Huang XY(黄新异); Di DL(邸多隆) |
Affiliation | 1.CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, China 2.Center of Resource Chemical and New Material, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Qingdao, China |
Recommended Citation GB/T 7714 | Huang XY,Pei D,Liu JF,et al. A review on chiral separation by counter-current chromatography: Development, applications and future outlook[J]. Journal of Chromatography A,2018,1531(0):1-12. |
APA | Huang XY,Pei D,Liu JF,&Di DL.(2018).A review on chiral separation by counter-current chromatography: Development, applications and future outlook.Journal of Chromatography A,1531(0),1-12. |
MLA | Huang XY,et al."A review on chiral separation by counter-current chromatography: Development, applications and future outlook".Journal of Chromatography A 1531.0(2018):1-12. |
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1-s2.0-S002196731731(1469KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text |
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