| Lipase-catalysed kinetic resolution of secondary alcohols with improved enantioselectivity in propylene carbonate | |
| Department | 羰基合成与选择氧化国家重点实验室 |
Wu XM(吴小梅); Sun W(孙伟) ; Xin JY(辛嘉英); Xia CG(夏春谷)
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| 2008 | |
| Source Publication | World Journal of Microbiology & Biotechnology
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| ISSN | 0959-3993 |
| Volume | 24Pages:2421-2424 |
| Abstract | The lipase-catalysed kinetic resolution of secondary alcohols was studied using vinyl acetate as acyl donor in propylene carbonate. Propylene carbonate offers an environmentally friendly alternative in contrast to conventional solvents. Several different lipases were investigated, and Candida antarctica lipase B (CALB) exhibited better results for all the substrates. It was shown that the addition of non-reactive base triethylamine and silver oxide to the reaction mixture enhanced the reaction rate and enantioselectivity. With propylene carbonate as solvent, CALB could be recycled without significant activity or enantioselectivity losses. |
| Keyword | Candida Antarctica Lipase Enantioselectivity Propylene Carbonate Triethylamine Vinyl Acetate |
| Subject Area | 清洁催化与生物转化 |
| Funding Organization | the NSFC (20625308;20643008);Chinese Academy of Sciences |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | 清洁催化与生物转化研究组 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/2278 |
| Collection | 羰基合成与选择氧化国家重点实验室（OSSO） |
| Corresponding Author | Sun W(孙伟); Xia CG(夏春谷) |
| Recommended Citation GB/T 7714 | Wu XM,Sun W,Xin JY,et al. Lipase-catalysed kinetic resolution of secondary alcohols with improved enantioselectivity in propylene carbonate[J]. World Journal of Microbiology & Biotechnology,2008,24:2421-2424. |
| APA | 吴小梅,孙伟,辛嘉英,&夏春谷.(2008).Lipase-catalysed kinetic resolution of secondary alcohols with improved enantioselectivity in propylene carbonate.World Journal of Microbiology & Biotechnology,24,2421-2424. |
| MLA | 吴小梅,et al."Lipase-catalysed kinetic resolution of secondary alcohols with improved enantioselectivity in propylene carbonate".World Journal of Microbiology & Biotechnology 24(2008):2421-2424. |
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