Highly Selective Construction of Medium-Sized Lactams by Palladium-Catalyzed Intramolecular Hydroaminocarbonylation of Aminoalkynes | |
Department | OSSO国家重点实验室 |
Hu Y(胡越)1,3; Huang HM(黄汉民)1,2; Huang HM(黄汉民) | |
2017 | |
Source Publication | Organic Letters |
ISSN | 1523-7060 |
Volume | 19Issue:19Pages:5070-5073 |
Abstract | A novel palladium-catalyzed intramolecular hydro-aminocarbonylation of aminoalkynes has been developed. This direct and operationally simple protocol provides a rapid and reliable approach to a diverse array of valuable seven- and eight-membered lactams with high chemoselectivity and regioselectivity. The high selectivity might be attributed to rational tuning the electronic nature of the amine moiety and the palladium catalyst, which enabled this transformation to proceed in the absence of acidic or any other additives under fairly mild reaction conditions. This method paves the way for the synthesis of medium-sized lactams. |
Subject Area | 物理化学与绿色催化 |
DOI | 10.1021/acs.orglett.7b02284 |
Funding Organization | the CAS Interdisciplinary Innovation Team;the National Natural Science Foundation of China (21672199) |
Indexed By | SCI |
If | 6.579 |
Language | 英语 |
compositor | 第一作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/22535 |
Collection | 羰基合成与选择氧化国家重点实验室(OSSO) |
Corresponding Author | Huang HM(黄汉民) |
Affiliation | 1.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Gansu, Peoples R China 2.Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
Recommended Citation GB/T 7714 | Hu Y,Huang HM,Huang HM. Highly Selective Construction of Medium-Sized Lactams by Palladium-Catalyzed Intramolecular Hydroaminocarbonylation of Aminoalkynes[J]. Organic Letters,2017,19(19):5070-5073. |
APA | Hu Y,Huang HM,&黄汉民.(2017).Highly Selective Construction of Medium-Sized Lactams by Palladium-Catalyzed Intramolecular Hydroaminocarbonylation of Aminoalkynes.Organic Letters,19(19),5070-5073. |
MLA | Hu Y,et al."Highly Selective Construction of Medium-Sized Lactams by Palladium-Catalyzed Intramolecular Hydroaminocarbonylation of Aminoalkynes".Organic Letters 19.19(2017):5070-5073. |
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