Improved surface imprinting based on a simplified mass-transfer process for the selective extraction of IgG | |
Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Ma RT(马润恬)1; Sun XY(孙晓宇)1,2; Ha W(哈伟)1; Chen J(陈娟)1; Shi YP(师彦平)1; Shi YP(师彦平) | |
2017 | |
Source Publication | Journal of Materials Chemistry B |
ISSN | 2050-750X |
Volume | 5Issue:36Pages:7512-7518 |
Abstract | We wished to improve the unsatisfactory adsorption and elution efficiencies in conventional magnetic molecular imprinting technology. In this work, a reliable strategy to prepare magnetic molecularly imprinted nanoparticles (MMINs) with rapid rebinding and elution speed was introduced. To decrease the mass-transfer retention of the templates, glycoprotein immunoglobulin (Ig)G was pre-immobilized to form homogeneous and monostratified three-dimensionally imprinted cavities on the surface of magnetic carriers. To shorten the transfer route of the templates, the polymerizaiton process was controlled precisely to form well-defined molecularly imprinted polymer (MIP) films of thickness 12 nm. In this way, the effectiveness of the mass transfer of the templates was maximized, and the length of the transfer route was minimized. As a result, the prepared MMINs showed improved adsorption and elution efficiencies compared with the conventional magnetic molecularly imprinted polymers (MMIPs), and exhibited great selectivity towards the templates. |
Subject Area | 分析化学与药物化学 |
DOI | 10.1039/c7tb01519d |
Funding Organization | the National Natural Science Foundation of China (21575150;21405164;21375136);the top priority program of ‘‘One-Three-Five’’ Strategic Planning of the Lanzhou Institute of Chemical Physics |
Indexed By | SCI |
If | 4.543 |
Language | 英语 |
Funding Project | 药物化学成分研究组 |
compositor | 第一作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/22510 |
Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Corresponding Author | Shi YP(师彦平) |
Affiliation | 1.CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, P. R. China 2.University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100049, P. R. China |
Recommended Citation GB/T 7714 | Ma RT,Sun XY,Ha W,et al. Improved surface imprinting based on a simplified mass-transfer process for the selective extraction of IgG[J]. Journal of Materials Chemistry B,2017,5(36):7512-7518. |
APA | Ma RT,Sun XY,Ha W,Chen J,Shi YP,&师彦平.(2017).Improved surface imprinting based on a simplified mass-transfer process for the selective extraction of IgG.Journal of Materials Chemistry B,5(36),7512-7518. |
MLA | Ma RT,et al."Improved surface imprinting based on a simplified mass-transfer process for the selective extraction of IgG".Journal of Materials Chemistry B 5.36(2017):7512-7518. |
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