External oxidant-free electrooxidative [3+2] annulation between phenol and indole derivatives | |
Department | OSSO国家重点实验室 |
Liu, Kun1; Tang, Shan1; Huang, Pengfei1; Lei AW(雷爱文)1,2; Lei AW(雷爱文) | |
2017 | |
Source Publication | Nature Communications |
ISSN | 2041-1723 |
Volume | 8Pages:775(1-8) |
Abstract | Intermolecular [3 + 2] annulation is one of the most straightforward approaches to construct five membered heterocycles. However, it generally requires the use of functionalized substrates. An ideal reaction approach is to achieve dehydrogenative [3 + 2] annulation under oxidant-free conditions. Here we show an electrooxidative [3 + 2] annulation between phenols and N-acetylindoles under undivided electrolytic conditions. Neither external chemical oxidants nor metal catalysts are required to facilitate the dehydrogenation processes. This reaction protocol provides an environmentally friendly way for the selective synthesis of benzofuroindolines. Various N-acetylindoles bearing different C-3 and C-2 substituents are suitable in this electrochemical transformation, furnishing corresponding benzofuroindolines in up to 99% yield. |
Subject Area | 物理化学与绿色催化 |
DOI | 10.1038/s41467-017-00873-1 |
Funding Organization | the National Natural Science Foundation of China (21390400;21520102003;21272180;21302148);the Hubei Province Natural Science Foundation of China (2013CFA081);the Research Fund for the Doctoral Program of Higher Education of China (20120141130002);the Ministry of Science and Technology of China (2012YQ120060);The Program of Introducing Talents of Discipline to Universities of China (111 Program) |
Indexed By | SCI |
If | 12.124 |
Language | 英语 |
compositor | 第二作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/22489 |
Collection | 羰基合成与选择氧化国家重点实验室(OSSO) |
Corresponding Author | Lei AW(雷爱文) |
Affiliation | 1.Wuhan Univ, IAS, Coll Chem & Mol Sci, Wuhan 430072, Hubei, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Gansu, Peoples R China |
Recommended Citation GB/T 7714 | Liu, Kun,Tang, Shan,Huang, Pengfei,et al. External oxidant-free electrooxidative [3+2] annulation between phenol and indole derivatives[J]. Nature Communications,2017,8:775(1-8). |
APA | Liu, Kun,Tang, Shan,Huang, Pengfei,Lei AW,&雷爱文.(2017).External oxidant-free electrooxidative [3+2] annulation between phenol and indole derivatives.Nature Communications,8,775(1-8). |
MLA | Liu, Kun,et al."External oxidant-free electrooxidative [3+2] annulation between phenol and indole derivatives".Nature Communications 8(2017):775(1-8). |
Files in This Item: | ||||||
File Name/Size | DocType | Version | Access | License | ||
s41467-017-00873-1.p(985KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text |
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment