Further New Gypenosides from Jiaogulan (Gynostemma pentaphyllum) | |
Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Wang J(王君)1,2; Yang JL(杨军丽)1; Zhou, Pan-Pan3; Meng XH(孟宪华)1; Shi YP(师彦平)1; Yang JL(杨军丽) | |
2017 | |
Source Publication | Journal of Agricultural and Food Chemistry |
ISSN | 0021-8561 |
Volume | 65Issue:29Pages:5926-5934 |
Abstract | Jiaogulan (Gynostemma pentaphyllum) has been widely used as a herbal tea, dietary supplement, and vegetable in Asian countries. In this study, six new gypenosides (1–6) were isolated from the aerial parts of G. pentaphyllum. Their molecular structures were elucidated through spectroscopic analysis and acid hydrolysis. Gypenosides 1 and 2 represented the first example of a dammar-21-O- glucopyranoside without any unsaturated functional group and a dammar-3-O-glucopyranosyl-25-O-glucopyranoside without any cyclization in the side chain, respectively. In addition, gypenosides 5 and 6 exhibited the first example of a 24-hydroperoxy-19-oxo-dammarane triterpenoid and 19-oxo-dammar-21-O-glucopyranoside with a saturated side chain, respectively. Gypenoside 5 was found to possess protein tyrosine phosphatase 1B inhibitory activity, with an IC50 value of 8.2 ± 0.9 μM, and moderate cytotoxicity against human breast cancer cells MCF7, MCF7/ADR, and MDA-MB-231, with IC50 values ranging from 10.5 ± 1.4 to 14.2 ± 2.6 μM. The outcome of the study provided crucial information regarding the structural diversity and health benefits of gypenosides. |
Keyword | Jiaogulan Gynostemma Pentaphyllum New Gypenosides Ptp1b Inhibitory Activity Cytotoxicity |
Subject Area | 分析化学与药物化学 |
DOI | 10.1021/acs.jafc.7b01477 |
Funding Organization | the National Natural Science Foundation of China (81673325);the CAS Pioneer Hundred Talents Program;the Top Priority Program of “One-Three-Five” Strategic Planning of the Lanzhou Institute of Chemical Physics of CAS |
Indexed By | SCI |
If | 3.154 |
Language | 英语 |
Funding Project | 药物化学成分研究组 |
compositor | 第一作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/22440 |
Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Corresponding Author | Yang JL(杨军丽) |
Affiliation | 1.CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, People’s Republic of China 2.University of Chinese Academy of Sciences, Beijing 100039, People’s Republic of China 3.College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, People’s Republic of China |
Recommended Citation GB/T 7714 | Wang J,Yang JL,Zhou, Pan-Pan,et al. Further New Gypenosides from Jiaogulan (Gynostemma pentaphyllum)[J]. Journal of Agricultural and Food Chemistry,2017,65(29):5926-5934. |
APA | Wang J,Yang JL,Zhou, Pan-Pan,Meng XH,Shi YP,&杨军丽.(2017).Further New Gypenosides from Jiaogulan (Gynostemma pentaphyllum).Journal of Agricultural and Food Chemistry,65(29),5926-5934. |
MLA | Wang J,et al."Further New Gypenosides from Jiaogulan (Gynostemma pentaphyllum)".Journal of Agricultural and Food Chemistry 65.29(2017):5926-5934. |
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