Asymmetric synthesis of CF3-containing tetrahydroquinoline via a thiourea-catalyzed cascade reaction

doi:10.1039/c7ob01013c

	Asymmetric synthesis of CF3-containing tetrahydroquinoline via a thiourea-catalyzed cascade reaction
Department	OSSO国家重点实验室
	Zhu, Yuanyuan 1; Li, Boyu 1; Wang, Cui 1; Dong, Zhenghao 1; Zhong, Xiaoling 1; Wang, Kairong 1; Yan, Wenjin 1; Wang R(王锐)1,2; Wang R(王锐)
	2017
Source Publication	Organic and Biomolecular Chemistry
ISSN	1477-0520
Volume	15 Issue:21 Pages:4544-4547
Abstract	An organocatalytic asymmetric method for the synthesis of 2-CF₃ tetrahydroquinoline has been achieved. The cascade reaction of 2-aminochalcones with β-CF₃ nitroalkenes afforded the products bearing three contiguous stereogenic centers in good yields with excellent diastereoselectivities and enantioselectivities.
Subject Area	物理化学与绿色催化
DOI	10.1039/c7ob01013c
Funding Organization	the National Natural Science Foundation of China (no. 81573265;21432003)
Indexed By	SCI
If	3.564
Language	英语
compositor	第二作者单位
Citation statistics	Cited Times:23[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.licp.cn/handle/362003/21974
Collection	羰基合成与选择氧化国家重点实验室（OSSO）
Corresponding Author	Yan, Wenjin; Wang R(王锐)
Affiliation	1.Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, Inst Pharmacol, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China
Recommended Citation GB/T 7714	Zhu, Yuanyuan,Li, Boyu,Wang, Cui,et al. Asymmetric synthesis of CF3-containing tetrahydroquinoline via a thiourea-catalyzed cascade reaction[J]. Organic and Biomolecular Chemistry,2017,15(21):4544-4547.
APA	Zhu, Yuanyuan.,Li, Boyu.,Wang, Cui.,Dong, Zhenghao.,Zhong, Xiaoling.,...&王锐.(2017).Asymmetric synthesis of CF3-containing tetrahydroquinoline via a thiourea-catalyzed cascade reaction.Organic and Biomolecular Chemistry,15(21),4544-4547.
MLA	Zhu, Yuanyuan,et al."Asymmetric synthesis of CF3-containing tetrahydroquinoline via a thiourea-catalyzed cascade reaction".Organic and Biomolecular Chemistry 15.21(2017):4544-4547.

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