Graphene oxide for solid-phase extraction of bioactive phenolic acids | |
Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Hou XD(侯秀丹)1,2; Wang XS(王旭生)1; Sun, Yingxin3; Wang LC(王立成)1; Guo Y(郭勇)1 | |
2017 | |
Source Publication | Analytical and Bioanalytical Chemistry |
ISSN | 1618-2642 |
Volume | 409Issue:14Pages:3541-3549 |
Abstract | A solid-phase extraction (SPE) method for the efficient analysis of trace phenolic acids (PAs, caffeic acid, ferulic acid, protocatechuic acid, cinnamic acid) in urine was established. In this work, a graphene oxide (GO) coating was grafted onto pure silica to be investigated as SPE material. The prepared GO surface had a layered and wrinkled structure that was rough and well organized, which could provide more open adsorption sites. Owing to its hydrophilicity and polarity, GO showed higher extraction efficiency toward PAs than reduced GO did, in agreement with the theoretical calculation results performed by Gaussian 09 software. The adsorption mechanism of PAs on GO@Sil was also investigated through static state and kinetic state adsorption experiments, which showed a monolayer surface adsorption. Extraction capacity of the as-prepared material was optimized using the response surface methodology. Under the optimized conditions, the as-established method provided wide linearity range (2–50 μg L−1 for protocatechuic acid and 1–50 μg L−1 for caffeic acid, ferulic acid, and cinnamic acid) and low limits of detection (0.25–1 μg L−1). Finally, the established method was applied for the analysis of urine from two healthy volunteers. The results indicate that the prepared material is a practical, cost-effective medium for the extraction and determination of phenolic acids in complex matrices. |
Keyword | Adsorption Mechanism Graphene Oxide Phenolic Acid Response Surface Methodology Solid-phase Extraction |
Subject Area | 分析化学与药物化学 |
DOI | 10.1007/s00216-017-0291-0 |
Funding Organization | the National Natural Science Foundation of China (21575149;21505146;21575148);Key Laboratory of Chemistry of Northwestern Plant Resources, Chinese Academy of Sciences, China (CNPR-2015kfkt-01) |
Indexed By | SCI |
If | 3.431 |
Language | 英语 |
Funding Project | 药物分离材料研究组 |
compositor | 第一作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/21905 |
Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Affiliation | 1.CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, China 2.Chinese Academy of Sciences, University of Chinese Academy of Sciences, Beijing, China 3.School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai, China |
Recommended Citation GB/T 7714 | Hou XD,Wang XS,Sun, Yingxin,et al. Graphene oxide for solid-phase extraction of bioactive phenolic acids[J]. Analytical and Bioanalytical Chemistry,2017,409(14):3541-3549. |
APA | Hou XD,Wang XS,Sun, Yingxin,Wang LC,&Guo Y.(2017).Graphene oxide for solid-phase extraction of bioactive phenolic acids.Analytical and Bioanalytical Chemistry,409(14),3541-3549. |
MLA | Hou XD,et al."Graphene oxide for solid-phase extraction of bioactive phenolic acids".Analytical and Bioanalytical Chemistry 409.14(2017):3541-3549. |
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