Tunable Aerobic Oxidative Hydroxylation/Dehydrogenative Homocoupling of Pyrazol-5-ones under Transition-Metal-Free Conditions

doi:10.1021/acs.orglett.7b00951

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	Tunable Aerobic Oxidative Hydroxylation/Dehydrogenative Homocoupling of Pyrazol-5-ones under Transition-Metal-Free Conditions
Department	苏州研究院
	Sheng, Xuguang 1,2; Zhang JL(张金龙)1; Yang HM(杨化萌)1; Jiang GX(蒋高喜)1; Jiang GX(蒋高喜)
The second department	osso国家重点实验室
	2017
Source Publication	Organic Letters
ISSN	1523-7060
Volume	19 Issue:10 Pages:2618-2621
Abstract	A practical and tunable transition-metal-free aerobic oxidation of pyrazol-5-ones preparing either 4-hydroxypyrazoles (via C–H hydroxylation) or bispyrazoles (via dehydrogenative homocoupling) is described. The K₂CO₃/dioxane reagent system predominately promoted hydroxylation to deliver the α-hydroxylated pyrazoles. In contrast, the formation of bispyrazoles was overwhelmingly preferred with CH₃CN as the reaction medium without any additives.
Subject Area	物理化学与绿色催化
DOI	10.1021/acs.orglett.7b00951
Funding Organization	the Hundred Talent Program of Chinese Academy of Science (CAS);the National Natural Science Foundation of China (21602231);the Natural Science Foundation of Jiangsu Peovince (Grant Nos. BK20151235;BK20160396)
Indexed By	SCI
If	6.579
Language	英语
compositor	第一作者单位
Citation statistics	Cited Times:22[WOS] [WOS Record] [Related Records in WOS]
Document Type	期刊论文
Identifier	http://ir.licp.cn/handle/362003/21874
Collection	苏州研究院羰基合成与选择氧化国家重点实验室（OSSO）
Corresponding Author	Jiang GX(蒋高喜)
Affiliation	1.Chinese Acad Sci, LICP, Suzhou Res Inst, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation GB/T 7714	Sheng, Xuguang,Zhang JL,Yang HM,et al. Tunable Aerobic Oxidative Hydroxylation/Dehydrogenative Homocoupling of Pyrazol-5-ones under Transition-Metal-Free Conditions[J]. Organic Letters,2017,19(10):2618-2621.
APA	Sheng, Xuguang,Zhang JL,Yang HM,Jiang GX,&蒋高喜.(2017).Tunable Aerobic Oxidative Hydroxylation/Dehydrogenative Homocoupling of Pyrazol-5-ones under Transition-Metal-Free Conditions.Organic Letters,19(10),2618-2621.
MLA	Sheng, Xuguang,et al."Tunable Aerobic Oxidative Hydroxylation/Dehydrogenative Homocoupling of Pyrazol-5-ones under Transition-Metal-Free Conditions".Organic Letters 19.10(2017):2618-2621.

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