Nanocellulose crystals derivative-silica hybrid sol open tubular capillary column for enantioseparation | |
Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Dong SQ(董树清)1; Sun YM(孙亚明)1,2; Zhang X(张霞)1; Li, Hui1; Luo GY(罗国英)1; Zhao L(赵亮)1; Zhao L(赵亮) | |
2017 | |
Source Publication | Carbohydrate Polymers |
ISSN | 0144-8617 |
Volume | 165Pages:359-367 |
Abstract | Broad spectrum separation of chiral compounds is a challenge task for analysts. It is significant for preparation of chiral stationary phase and selection of separation technology in the field. Here, we present a novel nanocellulose crystals (NCCs) which were derivation with 3,5-dimethylphenyl isocynate (DMPC) and silane with 3-triethoxysilylpropylisocyanate form sol in tetraethylorthosilicate (TEOS) and layer-by-layer self-assembly in the inner of capillary to fabricate the organic-inorganic hybrid open tubular capillary column (DMPC/NCCs-OTC) for enantiomers separation by capillary electrochromatography technology (CEC). The experimental results verified that this coating column has the broad spectrum separation ability and high resolution efficiency for thirteen different enantiomers at the optimal CEC conditions. The mechanizations of DMPC/NCCs-OTC modified layer numbers and structure effect on chiral separation performance have been investigated and compared. Although the limitation and difficulty in fabrication of open tubular coating column, this work provided the preparation method of stability, controlled, long column life, adequate repeatability and satisfied enantioseparation performance. |
Keyword | Nanocellulose Crystals Derivative Organic-inorganic Hybrid Layer-by-layer Self-assembly Open Tubular Capillary Column Enantioseparation |
Subject Area | 分析化学与药物化学 |
DOI | 10.1016/j.carbpol.2017.02.060 |
Funding Organization | the Natural Science Foundation of China (Grant Nos: 21405161;21675163) |
Indexed By | SCI |
If | 4.811 |
Language | 英语 |
Funding Project | 药物手性分离研究组 |
compositor | 第一作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/21805 |
Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Corresponding Author | Zhao L(赵亮) |
Affiliation | 1.Key laboratory of Chemistry of Northwestern Plant Resources and Key laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, The Chinese Academy of Sciences, Lanzhou 730000, PR China 2.University of Chinese Academy of Sciences, Beijing 100049, PR China |
Recommended Citation GB/T 7714 | Dong SQ,Sun YM,Zhang X,et al. Nanocellulose crystals derivative-silica hybrid sol open tubular capillary column for enantioseparation[J]. Carbohydrate Polymers,2017,165:359-367. |
APA | Dong SQ.,Sun YM.,Zhang X.,Li, Hui.,Luo GY.,...&赵亮.(2017).Nanocellulose crystals derivative-silica hybrid sol open tubular capillary column for enantioseparation.Carbohydrate Polymers,165,359-367. |
MLA | Dong SQ,et al."Nanocellulose crystals derivative-silica hybrid sol open tubular capillary column for enantioseparation".Carbohydrate Polymers 165(2017):359-367. |
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