Synthesis of L-Ascorbyl Flurbiprofenate by Lipase-Catalyzed Esterification and Transesterification Reactions | |
Department | OSSO国家重点实验室 |
Xin JY(辛嘉英)1,2; Sun, Li-rui1; Chen, Shu-ming3; Wang, Yan1; Xia CG(夏春谷)2; Xin JY(辛嘉英) | |
2017 | |
Source Publication | BioMed Research International |
ISSN | 2314-6133 |
Volume | 2017Pages:5751262(1-6) |
Abstract | The synthesis of L-ascorbyl flurbiprofenate was achieved by esterification and transesterification in nonaqueous organic medium with Novozym 435 lipase as biocatalyst. The conversion was greatly influenced by the kinds of organic solvents, speed of agitation, catalyst loading amount, reaction time, and molar ratio of acyl donor to L-ascorbic acid. A series of solvents were investigated, and tert-butanol was found to be the most suitable from the standpoint of the substrate solubility and the conversion for both the esterification and transesterification. When flurbiprofen was used as acyl donor, 61.0% of L-ascorbic acid was converted against 46.4% in the presence of flurbiprofen methyl ester. The optimal conversion of L-ascorbic acid was obtained when the initial molar ratio of acyl donor to ascorbic acid was 5 : 1. kinetics parameters were solved by Lineweaver-Burk equation under nonsubstrate inhibition condition. Since transesterification has lower conversion, from the standpoint of productivity and the amount of steps required, esterification is a better method compared to transesterification. |
Subject Area | 物理化学与绿色催化 |
DOI | 10.1155/2017/5751262 |
Funding Organization | the National Natural Science Foundation of China (21573055);the Scientfic Research Fund of Heilongjiang Province (GC13C111);the Open Project Program of the State Key Labortory For Oxo Synthesis and Selective Oxidation;the State Key Laboratory of Chemical Resource Engineering |
Indexed By | SCI |
If | 2.476 |
Language | 英语 |
Funding Project | 均相催化研究组 |
compositor | 第二作者单位 |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.licp.cn/handle/362003/21785 |
Collection | 羰基合成与选择氧化国家重点实验室(OSSO) |
Corresponding Author | Xin JY(辛嘉英) |
Affiliation | 1.Harbin Univ Commerce, Key Lab Food Sci & Engn, Harbin 150076, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China 3.Shanxi Agr Univ, Coll Anim Sci & Vet Med, Taigu 030801, Peoples R China |
Recommended Citation GB/T 7714 | Xin JY,Sun, Li-rui,Chen, Shu-ming,et al. Synthesis of L-Ascorbyl Flurbiprofenate by Lipase-Catalyzed Esterification and Transesterification Reactions[J]. BioMed Research International,2017,2017:5751262(1-6). |
APA | Xin JY,Sun, Li-rui,Chen, Shu-ming,Wang, Yan,Xia CG,&辛嘉英.(2017).Synthesis of L-Ascorbyl Flurbiprofenate by Lipase-Catalyzed Esterification and Transesterification Reactions.BioMed Research International,2017,5751262(1-6). |
MLA | Xin JY,et al."Synthesis of L-Ascorbyl Flurbiprofenate by Lipase-Catalyzed Esterification and Transesterification Reactions".BioMed Research International 2017(2017):5751262(1-6). |
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5751262.pdf(1566KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text |
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