| Asymmetric Synthesis of alpha-Trifluoromethyl Pyrrolidines through Organocatalyzed 1,3-Dipolar Cycloaddition Reaction | |
| Department | OSSO国家重点实验室 |
| Dong, Zhenghao1; Zhu, Yuanyuan1; Li, Boyu1; Wang, Cui1; Yan, Wenjin1; Wang, Kairong1; Wang R(王锐)1,2; Wang R(王锐) | |
| 2017 | |
| Source Publication | Journal of Organic Chemistry
 |
| ISSN | 0022-3263 |
| Volume | 82Issue:7Pages:3482-3490 |
| Abstract | The optically active α-trifluoromethyl pyrrolidines have been achieved through organocatalyzed 1,3-dipolar cycloaddition reaction first. With diphenylprolinol trimethylsilyl ether as catalyst and in the presence of 3,5-dinitrobenzoic acid, the reaction of trifluoroethylamine-derived ketimine with 2-enals gave α-trifluoromethyl pyrrolidines bearing three contiguous stereogenic centers in excellent diastereoselectivies, stereoselectivities, and yields. |
| Subject Area | 物理化学与绿色催化 |
| DOI | 10.1021/acs.joc.6b02949 |
| Funding Organization | the National Natural Science Foundation of China (Nos. 81573265;21432003) |
| Indexed By | SCI |
| If | 4.849 |
| Language | 英语 |
| compositor | 第二作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/21781 |
| Collection | 羰基合成与选择氧化国家重点实验室（OSSO） |
| Corresponding Author | Yan, Wenjin; Wang, Kairong; Wang R(王锐) |
| Affiliation | 1.Lanzhou Univ, Inst Pharmacol, Key Lab Preclin Study New Drugs Gansu Prov, Sch Basic,Med Sci, Lanzhou 730000, Peoples R China 2.Chinese Acad Sci, State Key Lab Oxo Synth & Select Oxidat, Lanzhou Inst Chem Phys, Lanzhou 730000, Peoples R China |
| Recommended Citation GB/T 7714 | Dong, Zhenghao,Zhu, Yuanyuan,Li, Boyu,et al. Asymmetric Synthesis of alpha-Trifluoromethyl Pyrrolidines through Organocatalyzed 1,3-Dipolar Cycloaddition Reaction[J]. Journal of Organic Chemistry,2017,82(7):3482-3490. |
| APA | Dong, Zhenghao.,Zhu, Yuanyuan.,Li, Boyu.,Wang, Cui.,Yan, Wenjin.,...&王锐.(2017).Asymmetric Synthesis of alpha-Trifluoromethyl Pyrrolidines through Organocatalyzed 1,3-Dipolar Cycloaddition Reaction.Journal of Organic Chemistry,82(7),3482-3490. |
| MLA | Dong, Zhenghao,et al."Asymmetric Synthesis of alpha-Trifluoromethyl Pyrrolidines through Organocatalyzed 1,3-Dipolar Cycloaddition Reaction".Journal of Organic Chemistry 82.7(2017):3482-3490. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| acs.joc.6b02949.pdf（901KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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