| Separation of antioxidant and -glucosidase inhibitory flavonoids from the aerial parts of Asterothamnus centrali-asiaticus | |
| Department | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
Wang YM(王衍明)1,2; Zhao, Jian-Qiang3; Yang JL(杨军丽)1,2 ; Tao, Yan-Duo3; Mei, Li-Juan3; Shi YP(师彦平)1,2; Shi YP(师彦平)
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| 2017 | |
| Source Publication | Natural Product Research
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| ISSN | 1478-6419 |
| Volume | 31Issue:12Pages:1365-1369 |
| Abstract | A new flavonoid, along with 16 known ones, was separated from the aerial parts of Asterothamnus centrali-asiaticus. Their structures were elucidated by extensive spectroscopic methods, including 1D and 2D NMR techniques and HRESIMS. To confirm the structure of the new compound, computational prediction of its 13C chemical shifts was performed. All of the 17 flavonoids were reported from A. centrali-asiaticus for the first time. In addition, all flavonoids were evaluated for their antioxidant and α-glucosidase inhibitory activities. The results showed that 10 of them exhibited antioxidant activity. Meanwhile, four flavonoids displayed α-glucosidase inhibitory effect with IC50 values ranging from 38.9 to 299.7 μM. |
| Keyword | Asterothamnus Centrali-asiaticus Flavonoids Antioxidants Alpha-glucosidase Inhibitors |
| Subject Area | 分析化学与药物化学 |
| DOI | 10.1080/14786419.2016.1247083 |
| Funding Organization | the National Nature Science Foundation of China [grant number 21375136];[grant number 21575150];the scientific research project of Central Asia Drug Discovery and Development Centre of Chinese Academy of Sciences [grant number CAM201404];the CAS Pioneer Hundred Talents Program |
| Indexed By | SCI |
| If | 1.828 |
| Language | 英语 |
| Funding Project | 药物化学成分研究组 |
| compositor | 第一作者单位 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.licp.cn/handle/362003/21532 |
| Collection | 中科院西北特色植物资源化学重点实验室/甘肃省天然药物重点实验室 |
| Corresponding Author | Shi YP(师彦平) |
| Affiliation | 1.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Chem Northwestern Plant Resources CAS, Lanzhou, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou, Peoples R China 3.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining, Peoples R China |
| Recommended Citation GB/T 7714 | Wang YM,Zhao, Jian-Qiang,Yang JL,et al. Separation of antioxidant and -glucosidase inhibitory flavonoids from the aerial parts of Asterothamnus centrali-asiaticus[J]. Natural Product Research,2017,31(12):1365-1369. |
| APA | Wang YM.,Zhao, Jian-Qiang.,Yang JL.,Tao, Yan-Duo.,Mei, Li-Juan.,...&师彦平.(2017).Separation of antioxidant and -glucosidase inhibitory flavonoids from the aerial parts of Asterothamnus centrali-asiaticus.Natural Product Research,31(12),1365-1369. |
| MLA | Wang YM,et al."Separation of antioxidant and -glucosidase inhibitory flavonoids from the aerial parts of Asterothamnus centrali-asiaticus".Natural Product Research 31.12(2017):1365-1369. |
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| File Name/Size | DocType | Version | Access | License | ||
| npr2016v31n12p1365-9（975KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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